Current and Future Treatment Options for Narcolepsy: A Review
- PMID: 28966734
- PMCID: PMC5611768
- DOI: 10.5935/1984-0063.20170004
Current and Future Treatment Options for Narcolepsy: A Review
Abstract
Narcolepsy is a chronic neurological sleep disorder with potentially disabling symptoms ranging from occupational concerns to mental health difficulties. Recent advances related to the neurobiological basis of narcolepsy have led to newer pharmacological treatment options and adjunctive behavioral techniques that support symptom management. This article outlines evidence-based pharmacologic therapies, behavioral techniques, and psychosocial costs related to narcolepsy. Psychosocial factors, although frequently acknowledged, deserve further attention and awareness from researchers and providers. The American Academy of Sleep Medicine's (AASM) Quality Measure Drivers and potential future treatment options are also discussed.
Keywords: Behavioral medicine; Narcolepsy; Pharmacologic actions; Psychosocial impact; Therapeutics.
Conflict of interest statement
CONFLICT OF INTEREST The authors have no conflicts of interest in this article.
Similar articles
-
Emerging treatments for narcolepsy and its related disorders.Expert Opin Emerg Drugs. 2010 Mar;15(1):139-58. doi: 10.1517/14728210903559852. Expert Opin Emerg Drugs. 2010. PMID: 20166851 Review.
-
Quality measures for the care of patients with narcolepsy.J Clin Sleep Med. 2015 Mar 15;11(3):335. doi: 10.5664/jcsm.4554. J Clin Sleep Med. 2015. PMID: 25700880 Free PMC article.
-
Pharmacological management of narcolepsy with and without cataplexy.Expert Opin Pharmacother. 2017 Jun;18(8):809-817. doi: 10.1080/14656566.2017.1323877. Epub 2017 May 17. Expert Opin Pharmacother. 2017. PMID: 28443381 Review.
-
Narcolepsy--master of disguise: evidence-based recommendations for management.Postgrad Med. 2009 May;121(3):99-104. doi: 10.3810/pgm.2009.05.2008. Postgrad Med. 2009. PMID: 19491546
-
EFNS guidelines on management of narcolepsy.Eur J Neurol. 2006 Oct;13(10):1035-48. doi: 10.1111/j.1468-1331.2006.01473.x. Eur J Neurol. 2006. PMID: 16987156
Cited by
-
Treatment of Excessive Daytime Sleepiness in Patients with Narcolepsy.Curr Treat Options Neurol. 2019 Nov 12;21(11):57. doi: 10.1007/s11940-019-0595-9. Curr Treat Options Neurol. 2019. PMID: 31713736 Review.
-
Effects of Pharmacotherapy Treatment on Patient-Reported Outcomes in a Narcolepsy and Idiopathic Hypersomnia Cohort.J Clin Sleep Med. 2019 Dec 15;15(12):1799-1806. doi: 10.5664/jcsm.8088. Epub 2019 Oct 30. J Clin Sleep Med. 2019. PMID: 31855165 Free PMC article.
-
Lisdexamfetamine to improve excessive daytime sleepiness and weight management in narcolepsy: a case series.Braz J Psychiatry. 2020;42(3):314-316. doi: 10.1590/1516-4446-2019-0544. Epub 2019 Dec 20. Braz J Psychiatry. 2020. PMID: 31859793 Free PMC article.
-
Type 1 Narcolepsy in Pregnancy: A Case Report and Review of Literature.AJP Rep. 2024 Apr 26;14(2):e120-e123. doi: 10.1055/a-2297-4583. eCollection 2024 Apr. AJP Rep. 2024. PMID: 38682093 Free PMC article.
-
Integrative sleep management: from molecular pathways to conventional and herbal treatments.Naunyn Schmiedebergs Arch Pharmacol. 2025 May 8. doi: 10.1007/s00210-025-04183-y. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 40338321 Review.
References
-
- Overeem S, Reading P, Bassetti CL. Narcolepsy. Sleep Med Clin. 2012;7(2):263–281. doi: 10.1016/j.jsmc.2012.03.013. - DOI
-
- Peacock J, Benca RM. Narcolepsy: clinical features, co-morbidities & treatment. Indian J Med Res. 2010;131:338–349. - PubMed
-
- American Academy of Sleep Medicine (AASM) The International Classification of Sleep Disorders - Third Edition (ICSD-3) Darien: American Academy of Sleep Medicine; 2014.
LinkOut - more resources
Full Text Sources
Other Literature Sources