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Comparative Study
. 2017 Oct 2;18(1):30.
doi: 10.1186/s40510-017-0184-y.

Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators

Tulika Tripathi  1 , Prateek Gupta  2 , Priyank Rai  2 , Jitender Sharma  3 , Vinod Kumar Gupta  3 , Navneet Singh  2
Affiliations
Comparative Study

Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators

Tulika Tripathi et al. Prog Orthod. .

Abstract

Background: With change in concepts of growth determination methods, there is a surge in the measurement of biomarkers for appraisal of growth status. Osteocalcin is a bone-specific protein and was observed to parallel the normal growth curve. Hence, the present study was intended to assess the levels of serum osteocalcin and serum insulin-like growth factor-1 (IGF-1) and compare them with cervical vertebral maturation index (CVMI) stages.

Methods: The cross-sectional study was performed on 150 subjects (75 males and 75 females) in the age group of 8-20 years and segregated into six CVMI stages. Serum osteocalcin and IGF-1 were estimated by ELISA. Mann-Whitney U test was used to compare the mean ranks of serum osteocalcin and serum IGF-1 with different CVMI stages. Spearman correlation was performed to find association between serum osteocalcin and serum IGF-1 across six CVMI stages.

Results: Peak serum IGF-1 levels were obtained at CVMI stages 4 and 3 for males and females, respectively, with insignificant difference between stages 3 and 4 in females. Peak serum osteocalcin levels were found at stage 5 and 3 for males and females with insignificant difference from other stages except stages 5 and 6 in males. A statistically significant correlation was seen between serum IGF-1 and serum osteocalcin across six CVMI stages (P < 0.01).

Conclusions: Osteocalcin followed IGF-1 across all CVMI stages but showed insignificant interstage differences.

Keywords: Biochemical markers; IGF-1; Osteocalcin.

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Figures

Fig. 1
Fig. 1
The distribution and comparison of mean serum IGF-1 levels in males and females in the six CVMI stages
Fig. 2
Fig. 2
The distribution and comparison of mean serum osteocalcin levels in males and females in the six CVMI stages
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