Regulations of Adipocyte Phenotype and Obesity by IRX3. Positive or Negative?

Takeshi Inagaki¹

Affiliations

Affiliation

¹ Laboratory of Epigenetics and Metabolism, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan. Electronic address: inagaki@gunma-u.ac.jp.

PMID: 28967609
PMCID: PMC5652291
DOI: 10.1016/j.ebiom.2017.09.032

Comment

Regulations of Adipocyte Phenotype and Obesity by IRX3. Positive or Negative?

Takeshi Inagaki. EBioMedicine. 2017 Oct.

. 2017 Oct:24:7-8.

doi: 10.1016/j.ebiom.2017.09.032. Epub 2017 Sep 25.

Author

Takeshi Inagaki¹

Affiliation

¹ Laboratory of Epigenetics and Metabolism, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan. Electronic address: inagaki@gunma-u.ac.jp.

PMID: 28967609
PMCID: PMC5652291
DOI: 10.1016/j.ebiom.2017.09.032

No abstract available

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IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk.
Zou Y, Lu P, Shi J, Liu W, Yang M, Zhao S, Chen N, Chen M, Sun Y, Gao A, Chen Q, Zhang Z, Ma Q, Ning T, Ying X, Jin J, Deng X, Shen B, Zhang Y, Yuan B, Kauderer S, Liu S, Hong J, Liu R, Ning G, Wang W, Gu W, Wang J. Zou Y, et al. EBioMedicine. 2017 Oct;24:64-75. doi: 10.1016/j.ebiom.2017.09.010. Epub 2017 Sep 13. EBioMedicine. 2017. PMID: 28988979 Free PMC article.

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IRX3 Overexpression Enhances Ucp1 Expression In Vivo.
Zhang Z, Wu Q, He Y, Lu P, Li D, Yang M, Gu W, Liu R, Hong J, Wang J. Zhang Z, et al. Front Endocrinol (Lausanne). 2021 Mar 10;12:634191. doi: 10.3389/fendo.2021.634191. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33776928 Free PMC article.
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References

1. Abe Y., Rozqie R., Matsumura Y., Kawamura T., Nakaki R., Tsurutani Y., Tanimura-Inagaki K., Shiono A., Magoori K., Nakamura K. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nat. Commun. 2015;6:7052. - PMC - PubMed
1. Claussnitzer M., Dankel S.N., Kim K.H., Quon G., Meuleman W., Haugen C., Glunk V., Sousa I.S., Beaudry J.L., Puviindran V. FTO obesity variant circuitry and adipocyte browning in humans. N. Engl. J. Med. 2015;373:895–907. - PMC - PubMed
1. Gorkin D.U., Ren B. Genetics: closing the distance on obesity culprits. Nature. 2014;507:309–310. - PubMed
1. Inagaki T., Sakai J., Kajimura S. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat. Rev. Mol. Cell Biol. 2016;17:480–495. - PMC - PubMed
1. Smemo S., Tena J.J., Kim K.H., Gamazon E.R., Sakabe N.J., Gomez-Marin C., Aneas I., Credidio F.L., Sobreira D.R., Wasserman N.F. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014;507:371–375. - PMC - PubMed

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Regulations of Adipocyte Phenotype and Obesity by IRX3. Positive or Negative?

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Regulations of Adipocyte Phenotype and Obesity by IRX3. Positive or Negative?

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