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Comment
. 2018 May;15(5):531-532.
doi: 10.1038/cmi.2017.95. Epub 2017 Oct 2.

IFN-γ in tissue-immune homeostasis and antitumor immunity

Byungsuk Kwon  1   2
Affiliations
Comment

IFN-γ in tissue-immune homeostasis and antitumor immunity

Byungsuk Kwon. Cell Mol Immunol. 2018 May.
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
IFN-γ signatures in healthy tissue and cancer. Low levels of IFN-γ are thought to be constitutively expressed in normal tissue. The IFN-γ receptor (IFNGR) may have a tonic activity in stimulating STAT1, which results in expression of low levels of interferon-stimulated genes (ISGs). This homeostatic program balances immune activation and immune suppression. In cancer, high levels of IFN-γ stimulate ISGs involved in immune activation, thereby inhibiting tumor growth. When chronic IFN-γ stimulation occurs, the IFN-γ signatures are shifted toward dominant expression of T cell inhibitory receptors and provide a tumor environment favoring tumor growth.
See this image and copyright information in PMC

Comment on

  • IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.
    Nirschl CJ, Suárez-Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, Chau D, Rezaee M, Kim TG, Huang R, Fuentes-Duculan J, Song-Zhao GX, Gulati N, Lowes MA, King SL, Quintana FJ, Lee YS, Krueger JG, Sarin KY, Yoon CH, Garraway L, Regev A, Shalek AK, Troyanskaya O, Anandasabapathy N. Nirschl CJ, et al. Cell. 2017 Jun 29;170(1):127-141.e15. doi: 10.1016/j.cell.2017.06.016. Cell. 2017. PMID: 28666115 Free PMC article.

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