Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct 12;53(82):11357-11359.
doi: 10.1039/c7cc03415f.

Alanine scan reveals modifiable residues in teixobactin

K H Chen  1 , S P Le, X Han, J M Frias, J S Nowick
Affiliations

Alanine scan reveals modifiable residues in teixobactin

K H Chen et al. Chem Commun (Camb). .

Abstract

An alanine scan of Lys10-teixobactin reveals that a cationic residue at position 10 is not necessary for antibiotic activity and that position 3 tolerates substitution without loss of activity. An unexpected correlation between poor aqueous solubility and better antibiotic activity of the teixobactin analogues is observed.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Teixobactin and analogues.
Fig. 2
Fig. 2
Tolerance of amino acids in Lys10-teixobactin toward substitution.
See this image and copyright information in PMC

References

    1. Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C and Lewis K, Nature, 2015, 517, 455. - PMC - PubMed
    1. Wu C, Pan Z, Yao G, Wang W, Fang L and Su W, RSC Adv, 2017, 7, 1923.
    1. Parmar A, Iyer A, Vincent CS, Van Lysebetten D, Prior SH, Madder A, Taylor EJ and Singh I, Chem. Commun, 2016, 52, 6025. - PubMed
    1. Jin K, Sam IH, Po KHL, Lin D, Zadeh EHG, Chen S, Yuan Y and Li X, Nat. Commun, 2016, 7, 12394. - PMC - PubMed
    1. Monaim SAHA, Jad YE, Acosta GA, Naicker T, Ramchuran EJ, El-Faham A, Govender T, Kruger HG, de la Torre BG and Albericio F, RSC Adv, 2016, 6, 73827.