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. 2017 Nov 27;216(9):1130-1140.
doi: 10.1093/infdis/jix446.

Meningococcal Carriage Following a Vaccination Campaign With MenB-4C and MenB-FHbp in Response to a University Serogroup B Meningococcal Disease Outbreak-Oregon, 2015-2016

Lucy A McNamara  1 , Jennifer Dolan Thomas  1 , Jessica MacNeil  1 , How Yi Chang  1 , Michael Day  2 , Emily Fisher  3   2 , Stacey Martin  1 , Tasha Poissant  2 , Susanna E Schmink  1 , Evelene Steward-Clark  1 , Laurel T Jenkins  1 , Xin Wang  1 , Anna Acosta  1 ; Oregon Meningococcal Carriage Team
Collaborators, Affiliations

Meningococcal Carriage Following a Vaccination Campaign With MenB-4C and MenB-FHbp in Response to a University Serogroup B Meningococcal Disease Outbreak-Oregon, 2015-2016

Lucy A McNamara et al. J Infect Dis. .

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] J Infect Dis. 2019 Nov 6;220(12):2019. doi: 10.1093/infdis/jiz398. J Infect Dis. 2019. PMID: 31556448 No abstract available.

Abstract

Background: Limited data exist on the impact of the serogroup B meningococcal (MenB) vaccines MenB-FHbp and MenB-4C on meningococcal carriage and herd protection. We therefore assessed meningococcal carriage following a MenB vaccination campaign in response to a university serogroup B meningococcal disease outbreak in 2015.

Methods: A convenience sample of students recommended for vaccination provided oropharyngeal swab specimens and completed questionnaires during 4 carriage surveys over 11 months. Isolates were tested by real-time polymerase chain reaction analysis, slide agglutination, and whole-genome sequencing. Vaccination history was verified via university records and the state immunization registry.

Results: A total of 4225 oropharyngeal swab specimens from 3802 unique participants were analyzed. Total meningococcal and genotypically serogroup B carriage prevalence among sampled students were stable, at 11%-17% and 1.2%-2.4% during each round, respectively; no participants carried the outbreak strain. Neither 1-3 doses of MenB-FHbp nor 1-2 doses of MenB-4C was associated with decreased total or serogroup B carriage prevalence.

Conclusions: While few participants completed the full MenB vaccination series, limiting analytic power, these data suggest that MenB-FHbp and MenB-4C do not have a large, rapid impact on meningococcal carriage and are unlikely to provide herd protection in the context of an outbreak response.

Keywords: MenB-4C; MenB-FHbp; Meningococcal disease; Neisseria meningitidis; carriage.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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