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. 2017 May 23;8(38):62998-63013.
doi: 10.18632/oncotarget.18071. eCollection 2017 Sep 8.

Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 non-small cell lung cancer

Huan-Huan Wang #  1 , Lei Deng #  2 , Qing-Lian Wen #  3 , Chun-Ze Zhang #  4 , Nicholas G Zaorsky  5 , Bai-Lin Zhang  1 , Jie Chen  1 , Xian-Liang Zeng  1 , Yao-Li Cui  6 , Yang-Yang Shi  7 , Hai-Ling Hou  1 , Wei Wang  1 , Bo Jiang  1 , Jun Wang  1 , Qing-Song Pang  1 , Lu-Jun Zhao  1 , Zhi-Yong Yuan  1 , Ping Wang  1 , Mao-Bin Meng  1
Affiliations

Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 non-small cell lung cancer

Huan-Huan Wang et al. Oncotarget. .

Abstract

Aims: The aim of this study was to evaluate the ideal timing of PORT in the management of completely resected (R0) Stage IIIA-N2 NSCLC.

Patients and methods: Between January 2008 and December 2015, patients with known histologies of pathologic Stage IIIA-N2 NSCLC who underwent R0 resection and received PORT concurrent with or prior to two sequential cycles of chemotherapy ("early PORT") or with PORT administered after two cycles of chemotherapy ("late PORT") at multiple hospitals. The primary endpoint was OS; secondary end points included pattern of the first failure, LRRFS, and DMFS. Kaplan-Meier OS, LRRFS, and DMFS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS, LRRFS, and DMFS.

Results: Of 112 included patients, 41 (36.6%) and 71 (63.4%) patients received early PORT and late PORT, respectively. The median OS, LRRFS, and DMFS were longer for those who received early PORT than for those who received late PORT at the median follow-up of 29.6 months (all p < 0.05). Uni- and multi-variate analyses showed that number of POCT cycles and the combination schedule of PORT and POCT were independent prognostic factors for OS, LRRFS, and DMFS.

Conclusions: Early PORT is associated with improved outcomes in pathologic Stage IIIA-N2 R0 NSCLC patients.

Keywords: multimodality therapy; non-small cell lung cancer; overall survival; postoperative chemotherapy; postoperative radiotherapy.

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Conflict of interest statement

CONFLICTS OF INTEREST We have no conflicts of interests.

Figures

Figure 1
Figure 1. Patient selection
NSCLC: non-small cell lung cancer; SLR: sublobar lung resection; CT: chemotherapy; RT: radiotherapy; MTT: molecular targeted therapies; EGFR-TKI: epidermal growth factor tyrosine kinase inhibitors; MLN: mediastinal lymph node; PORT: postoperative radiotherapy; POCT: postoperative chemotherapy.
Figure 2
Figure 2. Kaplan–Meier survival curves
(A) OS for all patients and separate groups; (B) LRRFS for all patients and separate groups; (C) DMFS for all patients and separate groups. OS: overall survival; yr: year; LRRFS: locoregional recurrence-free survival; DMFS: distant metastasis-free survival; PORT: postoperative radiotherapy; POCT: postoperative chemotherapy.
Figure 3
Figure 3. Treatment scheme and definition of “early” and “late” PORT
See this image and copyright information in PMC

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