Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 29;8(38):64395-64406.
doi: 10.18632/oncotarget.18888. eCollection 2017 Sep 8.

Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis

Xi Zhang #  1 , Xuan-Zhang Huang #  1 , Wen-Jun Chen  1 , Jian Wu  1 , You Chen  2 , Cong-Cong Wu  1 , Zhen-Ning Wang  3
Affiliations

Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis

Xi Zhang et al. Oncotarget. .

Abstract

Background: The associations between vitamin D status, including plasma 25-hydroxyvitamin D [25(OH)D] levels and vitamin D intake, and pancreatic cancer risk and mortality are inconsistent. The aims of this study are to evaluate the antitumor and therapeutic effects of vitamin D status for pancreatic cancer patients.

Methods: A literature search for relevant studies was conducted using PubMed and Embase databases. Risk ratio (RR), hazard ratio (HR), and 95% confidence interval (CI) were used as the effect measures. All statistical analyses were performed using Stata software 12.0.

Results: Our results indicated that high plasma 25(OH)D levels were inversely associated with pancreatic cancer mortality without significant heterogeneity (HR=0.81, 95% CI=0.68-0.96). However, high plasma 25(OH)D levels could not reduce pancreatic cancer risk (RR=1.02, 95% CI=0.66-1.57). Moreover, vitamin D intake was also not associated with pancreatic cancer risk (RR=1.11, 95% CI=0.67-1.86).

Conclusions: Our results indicate that high plasma 25(OH)D levels were significantly associated with improved survival in pancreatic cancer patients. However, there were no significant associations between vitamin D intake or plasma 25(OH)D levels and pancreatic cancer risk.

Keywords: 25-hydroxyvitamin D; mortality; pancreatic cancer; risk; vitamin D.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST All authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Literature search and study selection
Figure 2
Figure 2. Meta-analysis of the association between plasma 25(OH)D levels and pancreatic cancer mortality
Figure 3
Figure 3
Funnel plots assessing publication bias for plasma 25(OH)D levels and pancreatic cancer mortality (A) and pancreatic cancer risk (B).
Figure 4
Figure 4. Meta-analysis of the association between plasma 25(OH)D levels and pancreatic cancer risk
Figure 5
Figure 5. Meta-analysis of the association between vitamin D intake and pancreatic cancer risk
See this image and copyright information in PMC

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. - PubMed
    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7–30. - PubMed
    1. Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet. 2016;388:73–85. - PubMed
    1. Gillen S, Schuster T, Meyer Zum Buschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med. 2010;7:e1000267. - PMC - PubMed
    1. Rosen CJ. Clinical practice. Vitamin D insufficiency. N Engl J Med. 2011;364:248–254. - PubMed

LinkOut - more resources