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. 2017 Jun 29;8(38):64395-64406.
doi: 10.18632/oncotarget.18888. eCollection 2017 Sep 8.

Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis

Xi Zhang #  1 , Xuan-Zhang Huang #  1 , Wen-Jun Chen  1 , Jian Wu  1 , You Chen  2 , Cong-Cong Wu  1 , Zhen-Ning Wang  3
Affiliations

Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis

Xi Zhang et al. Oncotarget. .

Abstract

Background: The associations between vitamin D status, including plasma 25-hydroxyvitamin D [25(OH)D] levels and vitamin D intake, and pancreatic cancer risk and mortality are inconsistent. The aims of this study are to evaluate the antitumor and therapeutic effects of vitamin D status for pancreatic cancer patients.

Methods: A literature search for relevant studies was conducted using PubMed and Embase databases. Risk ratio (RR), hazard ratio (HR), and 95% confidence interval (CI) were used as the effect measures. All statistical analyses were performed using Stata software 12.0.

Results: Our results indicated that high plasma 25(OH)D levels were inversely associated with pancreatic cancer mortality without significant heterogeneity (HR=0.81, 95% CI=0.68-0.96). However, high plasma 25(OH)D levels could not reduce pancreatic cancer risk (RR=1.02, 95% CI=0.66-1.57). Moreover, vitamin D intake was also not associated with pancreatic cancer risk (RR=1.11, 95% CI=0.67-1.86).

Conclusions: Our results indicate that high plasma 25(OH)D levels were significantly associated with improved survival in pancreatic cancer patients. However, there were no significant associations between vitamin D intake or plasma 25(OH)D levels and pancreatic cancer risk.

Keywords: 25-hydroxyvitamin D; mortality; pancreatic cancer; risk; vitamin D.

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Conflict of interest statement

CONFLICTS OF INTEREST All authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Literature search and study selection
Figure 2
Figure 2. Meta-analysis of the association between plasma 25(OH)D levels and pancreatic cancer mortality
Figure 3
Figure 3
Funnel plots assessing publication bias for plasma 25(OH)D levels and pancreatic cancer mortality (A) and pancreatic cancer risk (B).
Figure 4
Figure 4. Meta-analysis of the association between plasma 25(OH)D levels and pancreatic cancer risk
Figure 5
Figure 5. Meta-analysis of the association between vitamin D intake and pancreatic cancer risk
See this image and copyright information in PMC

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