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. 1988 May 14;1(8594):1065-7.
doi: 10.1016/s0140-6736(88)91893-4.

Identification of human herpesvirus-6 as a causal agent for exanthem subitum

K Yamanishi  1 , T Okuno, K Shiraki, M Takahashi, T Kondo, Y Asano, T Kurata
Affiliations

Identification of human herpesvirus-6 as a causal agent for exanthem subitum

K Yamanishi et al. Lancet. .

Abstract

A virus was isolated from the peripheral blood lymphocytes of patients with exanthem subitum, cultured successfully in cord blood lymphocytes, and shown to be antigenically related to human herpesvirus-6 (HHV-6). Morphological features, as studied by thin-section electronmicroscopy, resembled those of herpes group viruses. Convalescent-phase serum samples, tested against the new viral antigen and HHV-6 antigen, showed seroconversion. The results strongly suggest that the newly isolated virus is identical or closely related to HHV-6 and the causal agent for exanthem subitum.

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