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. 2017 Sep;21(9):573-577.
doi: 10.4103/ijccm.IJCCM_240_17.

Epidemiology of Adult-population Sepsis in India: A Single Center 5 Year Experience

Sharmila Chatterjee  1 , Mahuya Bhattacharya  2 , Subhash Kumar Todi  1   2
Affiliations

Epidemiology of Adult-population Sepsis in India: A Single Center 5 Year Experience

Sharmila Chatterjee et al. Indian J Crit Care Med. 2017 Sep.

Abstract

Background and aims: Sepsis is a major worldwide cause of morbidity and mortality. Most sepsis epidemiologic data are from the Western literature. Sparse data from India describe the epidemiology of infection rather than sepsis which is a host response to infection. This study describes the epidemiology of sepsis in the Intensive Care Unit (ICU) of an Indian tertiary care hospital.

Subjects and methods: A prospective study conducted between June 2006 and May 2011. All consecutively admitted patients during the 5 year study >=18 years of age were included and data obtained from hospital in-patient records. Variables measured were the incidence of severe sepsis, ICU, hospital, and 28-day mortality, the median length of ICU stay, median Acute Physiology and Chronic Health Evaluation II (APACHE II) score, infection site, and microbial profile.

Results: There were 4711 admissions during the study with 282 (6.2%, 95% confidence interval 2.3, 13.1) admissions with severe sepsis. ICU mortality, hospital mortality, and 28-day mortality were 56%, 63.6%, and 62.8%, respectively. Predominant infection site was respiratory tract. The most common organisms were Gram-negative microbes. The most common microbe was Acinetobacter baumanni. Median APACHE II score on admission was 22 (interquartile range 16-28) and median length of ICU stay was 8 days. Severe sepsis attributable mortality was 85%.

Conclusion: Severe sepsis is common in Indian ICUs and is mainly due to Gram-negative organisms. ICU mortality is high in this group and care is resource intensive due to increased length of stay.

Keywords: Epidemiology; intensive care patients; mortality; prevalence; severe sepsis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Summarizes the total number of severe sepsis patients and their outcomes during the study
See this image and copyright information in PMC

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