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Review
. 2017 Sep;7(3):262-265.
doi: 10.1016/j.jceh.2017.05.002. Epub 2017 May 15.

Toward a Better Definition of Acute-on-Chronic Liver Failure

Ajay Duseja  1 , Shivaram P Singh  2
Affiliations
Review

Toward a Better Definition of Acute-on-Chronic Liver Failure

Ajay Duseja et al. J Clin Exp Hepatol. 2017 Sep.

Abstract

Acute-on-chronic liver failure (ACLF) has been defined differently in the East and West. The definitions given by Asian Pacific association for the study of liver (APASL) and American association for the study of liver (AASLD) and European association for the study of liver (EASL) working group have fundamental deficiencies and contradictions and do not encompass all patients with ACLF seen in the East and West. Although the World Gastroenterology Organisation (WGO) working party attempted to provide an improved definition but this too is not appropriate. In this article, we have compared the various definitions of ACLF given by APASL, EASL-AASLD and WGO and suggest a comprehensive definition for prospective collection of data on ACLF.

Keywords: AASLD, American association for the study of liver diseases; ACLF; ACLF, Acute-on-chronic liver failure; APASL, The Asian Pacific association for the study of the liver; CLD, chronic liver disease; CLIF-C, chronic liver failure consortium; EASL, European Association for the Study of the Liver; WGO, World Gastroenterology Organisation; acute-on-chronic liver failure; chronic liver disease; cirrhosis; hepatic failure.

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References

    1. Jalan R., Williams R. Acute-on-chronic liver failure: pathophysiological basis and therapeutic options. Blood Purif. 2002;20:252–261. - PubMed
    1. Olson J.C., Kamath P.S. Acute-on-chronic liver failure: concept, natural history and prognosis. Curr Opin Crit Care. 2011;17:165–169. - PubMed
    1. Laleman W., Verbeke L., Meersseman P. Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions. Expert Rev Gastroenterol Hepatol. 2011;5:523–537. - PubMed
    1. Jalan R., Saliba F., Pavesi M., Amoros A., Moreau R., Ginès P. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61:1038–1047. - PubMed
    1. Gustot T., Fernandez J., García E. Short-term (28-day) clinical course and transplant-free mortality in acute-on-chronic liver failure (ACLF): evidence for reversibility of ACLF (a study from the CANONIC database) J Hepatol. 2014;60:S228.

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