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Review
. 2018 Jun;9(3):238-250.
doi: 10.1007/s12975-017-0570-2. Epub 2017 Oct 2.

Cerebral Hypoperfusion and Other Shared Brain Pathologies in Ischemic Stroke and Alzheimer's Disease

Shuying Dong  1   2 , Shelly Maniar  2   3 , Mioara D Manole  4 , Dandan Sun  5   6
Affiliations
Review

Cerebral Hypoperfusion and Other Shared Brain Pathologies in Ischemic Stroke and Alzheimer's Disease

Shuying Dong et al. Transl Stroke Res. 2018 Jun.

Abstract

Newly emerged evidence reveals that ischemic stroke and Alzheimer's disease (AD) share pathophysiological changes in brain tissue including hypoperfusion, oxidative stress, immune exhaustion, and inflammation. A mechanistic link between hypoperfusion and amyloid β accumulation can lead to cell damage as well as to motor and cognitive deficits. This review will discuss decreased cerebral perfusion and other related pathophysiological changes common to both ischemic stroke and AD, such as vascular damages, cerebral blood flow alteration, abnormal expression of amyloid β and tau proteins, as well as behavioral and cognitive deficits. Furthermore, this review highlights current treatment options and potential therapeutic targets that warrant further investigation.

Keywords: Alzheimer’s disease; Amyloid β; Cerebral blood flow; Hypoperfusion; Stroke; Tau protein; Treatment.

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Conflict of interest statement

Conflict of Interest Shuying Dong, Shelly Maniar, Mioara D. Manole, and Dandan Sun declare that they have no conflicts of interest to disclose.

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