Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;42(6):877-83.

Extensive DNA polymorphism at the factor XIIIa (F13A) locus and linkage to HLA

H Y Zoghbi  1 , S P Daiger, A McCall, W E O'Brien, A L Beaudet
Affiliations

Extensive DNA polymorphism at the factor XIIIa (F13A) locus and linkage to HLA

H Y Zoghbi et al. Am J Hum Genet. 1988 Jun.

Abstract

A 1,161-bp EcoRI fragment from the 5' end of the cDNA coding for human factor XIIIa (gene symbol F13A) was used to identify RFLPs in human DNAs. Several different RFLPs were identified with 15 different restriction enzymes. Two RFLPs detected with the restriction enzyme BamHI and one multiallelic RFLP detected with BclI were used for further studies. Linkage relationships between these three polymorphisms and the HLA complex were studied in DNA samples from the 40 Centre d'Etude du Polymorphisme Humain families. Combining all of the data to form highly informative haplotypes, we found linkage to HLA with a maximum lod score of 11.44 at a recombination fraction of .25 for males and .35 for females. These three RFLPs at the FXIIIa locus provide a highly informative marker for the short arm of chromosome 6 with an observed heterozygosity of 91%. Using this marker and the HLA locus, one can confirm or exclude the assignment of gene loci to most of chromosome 6p.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8019-23 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5165-9 - PubMed
    1. Science. 1987 Mar 27;235(4796):1616-22 - PubMed
    1. Am J Hum Genet. 1988 Jan;42(1):173-7 - PubMed
    1. J Biol Chem. 1973 Feb 25;248(4):1395-407 - PubMed

Publication types

LinkOut - more resources