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Review
. 2017 Oct 3;318(13):1272-1274.
doi: 10.1001/jama.2017.12131.

Cancer DNA in the Circulation: The Liquid Biopsy

Hatim Husain  1 , Victor E Velculescu  2
Affiliations
Review

Cancer DNA in the Circulation: The Liquid Biopsy

Hatim Husain et al. JAMA. .
No abstract available

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Conflict of interest statement

Conflict of Interest Diclosures: Both authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Husain reports participation on clinical advisory boards for Foundation Medicine, Abbvie, and AstraZeneca; a grant from Pfizer; and lecture honoraria from Bristol-Myers Squibb, Merck, and AstraZeneca. Dr Velculescu reports scientific advisory board and board of directors membership, stock ownership (subject to certain restrictions under university policy), and being a founder of Personal Genome Diagnostics; and being a member of the Ignyta scientific advisory board. The terms of these arrangements are managed by the Johns Hopkins University in accordance with its conflict of interest policies.

Figures

Figure
Figure. Analysis of ctDNA and Clinical Applications
A variety of tumor-derived genomic alterations may be detected in cfDNA (see text for description of methods for cfDNA analysis). Current clinical applications include treatment selection and identification of resistance mutations; future applications include monitoring of treatment response, detection of recurrence, and screening.
See this image and copyright information in PMC

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