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Comment
. 2017 Oct;7(10):1065-1066.
doi: 10.1158/2159-8290.CD-17-0860.

Targeting the Noncoding Genome: Superenhancers Meet Their Kryptonite

Eric Wang  1 , Ioannis Aifantis  1
Affiliations
Comment

Targeting the Noncoding Genome: Superenhancers Meet Their Kryptonite

Eric Wang et al. Cancer Discov. 2017 Oct.

Abstract

<b/> In this study, McKeown and colleagues carried out a genome-wide characterization and stratification of the enhancer landscape in acute myeloid leukemia (AML). The authors' analysis led to the discovery of a novel RARA superenhancer found in a subset of patients with AML, rendering these leukemia cells highly sensitive to SY-1425, a highly potent RARA agonist able to induce myeloid differentiation in these high-expressing RARA AML subtypes. Cancer Discov; 7(10); 1065-6. ©2017 AACR.See related article by McKeown et al., p. 1136.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Comment on

References

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