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Case Reports
. 2016 Fall;11(5):478-482.
Epub 2017 Jan 1.

Bilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis

Thin Thin Win  1 , Nik Mohamed Zaki Nik Mahmood  2 , Saung Oo Ma  2 , Mazita Ismail  3
Affiliations
Case Reports

Bilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis

Thin Thin Win et al. Iran J Pathol. 2016 Fall.

Abstract

Clear cell carcinoma of ovary is uncommon ovarian tumour that arises from surface epithelium of ovary. It has well-known association with ovarian endometriosis. We report here the first case of bilateral clear cell carcinoma of ovaries in a 40-year-old woman with a 17-year history of bilateral ovarian endometriosis. In addition, during the longstanding duration of the endometriosis, the patient was treated with hormonal therapy, including oestrogen. It represents the first report of such bilateral involvement in the background of ovarian endometriosis. This should prompt clinicians to be aware that prolonged hormonal treatment of endometriosis may precipitate bilateral malignancy of the ovary.

Keywords: Clear Cell Carcinoma; Malignant Transformation; Ovarian Endometriosis.

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Figures

Fig. 1
Fig. 1
a) Right ovarian tumor which is mainly cystic and partly solid at the periphery. (b) Left ovarian tumor which is partly solid and partly cystic; Both cystic walls are lined by old hemorrhagic areas
Fig. 2
Fig. 2
H & E stain (a) Clear cell carcinoma with papillary configuration lined by pleomorphic hobnail cells (X200); (b) Clear cell carcinoma showed large cells with clear abundant cytoplasm and some of the cytoplasm of the cell containing eosinophilic hyaline bodies (X400); (c) Foci of endometriosis in close proximity with clear cell carcinoma of right ovary (X100
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