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Case Reports
. 2017 Aug 29;9(2):6420.
doi: 10.4081/rt.2017.6420. eCollection 2017 Jul 3.

Granular Cell Tumor of Cecum: A Common Tumor in a Rare Site with Diagnostic Challenge

Meyyappa Devan Rajagopal  1 , Debasis Gochhait  1 , Dasarathan Shanmugan  2 , Adarsh Wamanrao Barwad  1
Affiliations
Case Reports

Granular Cell Tumor of Cecum: A Common Tumor in a Rare Site with Diagnostic Challenge

Meyyappa Devan Rajagopal et al. Rare Tumors. .

Abstract

Granular cell tumor (GCT) also known as Abrikossoff's tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. It is most frequently seen in the oral cavity, skin, and subcutaneous tissue. Gastrointestinal tract involvement is uncommon, in which esophagus is the most commonly affected site. There are case reports of GCT in stomach, appendix, colon and rectum. In this article, we report a case of GCT involving cecum. The cell of origin in GCT is controversial. There are various pools of thoughts regarding its histogenesis, the details of which are reviewed in this article with emphasis on the diagnostic difficulties encountered in this tumor.

Keywords: Cecum; Diagnostic pitfalls; Granular cell tumor.

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Figures

Figure 1.
Figure 1.
A) Non diagnostic intestinal mucosal biopsy. B) Well circumscribed tumor in muscularis propria. Overlying mucosa and submucosa are free of tumor. C) Tumor cells showing abundant coarse granular eosinophilic cytoplasm. Hematoxylin & Eosin; respectively 20×, 40×, 400× magnification.
Figure 2.
Figure 2.
Contrast enhanced computed tomography scan abdomen highlighted the small circumscribed mass in the caecum.
Figure 3.
Figure 3.
A) PAS positive granules in the cytoplasm of tumor cells; B) Luxol fast blue stain showing positive reaction in the granules of the tumor cells; C) S-100 showing strong nuclear and cytoplasmic positivity in the tumor cells; D) NSE showing weak diffuse positivity in the tumor cells (all images are 400× magnification).
Figure 4.
Figure 4.
A) Desmin staining the normal muscularis layer however tumor cells below are negative (100×); B) Immunostain for CD-117 is negative in the tumor area (400×); C) CD-34 highlights scattered endothelial cells however tumor cells are negative (400×).
See this image and copyright information in PMC

References

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