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. 2017 Jul;6(3):157-162.
doi: 10.15171/jnp.2017.27. Epub 2017 Feb 3.

The effect of zinc on healing of renal damage in rats

Mehdi Salehipour  1 , Ahmad Monabbati  2 , Mohammad Reza Ensafdaran  1 , Ali Adib  3 , Amir Hossein Babaei  3
Affiliations

The effect of zinc on healing of renal damage in rats

Mehdi Salehipour et al. J Nephropathol. 2017 Jul.

Abstract

Background: Several studies have previously been performed to promote kidney healing after injuries. Objectives: The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats.

Materials and methods: Forty healthy female rats were selected and one of their kidneys was incised. Half of the incisions were limited only to the cortex (renal injury type I) and the other ones reached the pelvocalyceal system of the kidney (renal injury type II). All the rats in the zinc treated group (case group) received 36.3 mg zinc sulfate (contained 8.25 mg zinc) orally. After 28 days, the damaged kidneys were removed for histopathological studies.

Results: In the rats with type I injury, kidney inflammation of the case group was significantly lower than that of the control group. However, the result was not significant in rats with type II injury. Tissue loss and granulation tissue formation were significantly lower in the case group than the control group in both type I and II kidney injuries.

Conclusions: Overall, Zinc can contribute to better healing of the rat's kidneys after a traumatic injury.

Keywords: Kidney; Trauma; Wound Healing; Zinc.

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