Sedentary time and postmenopausal breast cancer incidence

doi:10.1007/s10552-017-0968-x

. 2017 Dec;28(12):1405-1416.

doi: 10.1007/s10552-017-0968-x. Epub 2017 Oct 3.

Sedentary time and postmenopausal breast cancer incidence

Sarah J O Nomura¹, Chiranjeev Dash², Vanessa B Sheppard³, Deborah Bowen⁴, Matthew Allison⁵, Wendy Barrington⁶, Rowan Chlebowski⁷, Mace Coday⁸, Lifang Hou⁹, Barbara Howard¹⁰, Michael LaMonte¹¹, JoAnn E Manson^{12

13}, Marian L Neuhouser¹⁴, Electra Paskett¹⁵, Maryam Sattari¹⁶, Marcia Stefanick¹⁷, Jean Wactawski-Wende¹¹, Lucile L Adams-Campbell²

Affiliations

¹ Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 1000 New Jersey Ave SE, Washington, DC, 20003, USA. sjo36@georgetown.edu.
² Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 1000 New Jersey Ave SE, Washington, DC, 20003, USA.
³ Department of Health Behavior and Policy, School of Medicine, Virginia Commonwealth University, 830 East Main Street, Richmond, VA, 23219, USA.
⁴ Department of Bioethics and Humanities, University of Washington, Health Sciences Building, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
⁵ Department of Family Medicine and Public Health, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
⁶ Department of Epidemiology, School of Public Health, University of Washington, Health Sciences Building, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
⁷ Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
⁸ Department of Preventive Medicine, The University of Tennessee Health Science Center, Doctors Office Building, 66 North Pauline Street, Memphis, TN, 38163, USA.
⁹ Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Chicago, IL, 60611, USA.
¹⁰ MedStar Health Research Institute, 6525 Belcrest Road, Hyattsville, MD, 20782, USA.
¹¹ Department of Epidemiology and Environmental Health, University at Buffalo, 401 Kimball Tower, Buffalo, NY, 14214, USA.
¹² Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, 900 Commonwealth Avenue, Boston, MA, 02215, USA.
¹³ Department of Epidemiology, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
¹⁴ Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109, USA.
¹⁵ Division of Cancer Prevention and Control, College of Medicine, The Ohio State University, 370 W 9th Ave, Columbus, OH, 43210, USA.
¹⁶ Department of Internal Medicine, University of Florida College of Medicine, 2000 SW Archer Rd, Gainesville, FL, 3260, USA.
¹⁷ Department of Medicine, Stanford Prevention Research Center, Stanford University, Stanford, California, 1265 Welch Rd, Palo Alto, CA, 94305, USA.

PMID: 28975422
PMCID: PMC5687985
DOI: 10.1007/s10552-017-0968-x

Sedentary time and postmenopausal breast cancer incidence

Sarah J O Nomura et al. Cancer Causes Control. 2017 Dec.

. 2017 Dec;28(12):1405-1416.

doi: 10.1007/s10552-017-0968-x. Epub 2017 Oct 3.

Authors

Affiliations

¹ Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 1000 New Jersey Ave SE, Washington, DC, 20003, USA. sjo36@georgetown.edu.
² Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 1000 New Jersey Ave SE, Washington, DC, 20003, USA.
³ Department of Health Behavior and Policy, School of Medicine, Virginia Commonwealth University, 830 East Main Street, Richmond, VA, 23219, USA.
⁴ Department of Bioethics and Humanities, University of Washington, Health Sciences Building, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
⁵ Department of Family Medicine and Public Health, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
⁶ Department of Epidemiology, School of Public Health, University of Washington, Health Sciences Building, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
⁷ Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
⁸ Department of Preventive Medicine, The University of Tennessee Health Science Center, Doctors Office Building, 66 North Pauline Street, Memphis, TN, 38163, USA.
⁹ Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Chicago, IL, 60611, USA.
¹⁰ MedStar Health Research Institute, 6525 Belcrest Road, Hyattsville, MD, 20782, USA.
¹¹ Department of Epidemiology and Environmental Health, University at Buffalo, 401 Kimball Tower, Buffalo, NY, 14214, USA.
¹² Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, 900 Commonwealth Avenue, Boston, MA, 02215, USA.
¹³ Department of Epidemiology, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
¹⁴ Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109, USA.
¹⁵ Division of Cancer Prevention and Control, College of Medicine, The Ohio State University, 370 W 9th Ave, Columbus, OH, 43210, USA.
¹⁶ Department of Internal Medicine, University of Florida College of Medicine, 2000 SW Archer Rd, Gainesville, FL, 3260, USA.
¹⁷ Department of Medicine, Stanford Prevention Research Center, Stanford University, Stanford, California, 1265 Welch Rd, Palo Alto, CA, 94305, USA.

PMID: 28975422
PMCID: PMC5687985
DOI: 10.1007/s10552-017-0968-x

Abstract

Purpose: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements.

Methods: The Women's Health Initiative Observational Study is a prospective cohort among women ages 50-79 years at baseline (1994-1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity.

Results: Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6-9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92-1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements.

Conclusions: Results from this study do not support an association between sedentary time and breast cancer incidence.

Keywords: Body composition; Breast cancer; Physical activity; Sedentary; Sitting time.

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References

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[1] U.S. Center for Disease Control. [Accessed February 27 2017];Breast Cancer Statistics. 2016 https://www.cdc.gov/cancer/breast/statistics/

[2] U.S. Center for Disease Control. [Accessed February 27 2017];Breast Cancer Statistics. 2016 https://www.cdc.gov/cancer/breast/statistics/

[3] U.S. National Cancer Institute. [Accessed February 27 2017];SEER Cancer Stat Facts: Female Breast Cancer. 2016 https://seer.cancer.gov/statfacts/html/breast.html.

[4] U.S. National Cancer Institute. [Accessed February 27 2017];SEER Cancer Stat Facts: Female Breast Cancer. 2016 https://seer.cancer.gov/statfacts/html/breast.html.

[5] World Cancer Research Fund/American Association for Cancer Research. Contiuous Update Project Report. [Accessed August 3 2016];Food, Nutrition, Physical Activity, and the Prevention of Breast Cancer. 2010 http://www.wcrf.org/int/research-we-fund/continuous-update-project-findi....

[6] World Cancer Research Fund/American Association for Cancer Research. Contiuous Update Project Report. [Accessed August 3 2016];Food, Nutrition, Physical Activity, and the Prevention of Breast Cancer. 2010 http://www.wcrf.org/int/research-we-fund/continuous-update-project-findi....

[7] Lynch BM. Sedentary behavior and cancer: a systematic review of the literature and proposed biological mechanisms. Cancer Epidemiol Biomarkers Prev. 2010;19(11):2691–2709. doi: 10.1158/1055-9965.EPI-10-0815. - DOI - PubMed

[8] Lynch BM. Sedentary behavior and cancer: a systematic review of the literature and proposed biological mechanisms. Cancer Epidemiol Biomarkers Prev. 2010;19(11):2691–2709. doi: 10.1158/1055-9965.EPI-10-0815. - DOI - PubMed

[9] Zhou Y, Zhao H, Peng C. Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies. Ann Epidemiol. 2015;25(9):687–697. doi: 10.1016/j.annepidem.2015.05.007. - DOI - PubMed

[10] Zhou Y, Zhao H, Peng C. Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies. Ann Epidemiol. 2015;25(9):687–697. doi: 10.1016/j.annepidem.2015.05.007. - DOI - PubMed

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Sedentary time and postmenopausal breast cancer incidence

Affiliations

Sedentary time and postmenopausal breast cancer incidence

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