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Multicenter Study
. 2018 Mar;90(3):421-428.
doi: 10.1002/jmv.24963. Epub 2017 Nov 9.

Etiology of community-acquired pneumonia in 1500 hospitalized children

Hao Oumei  1 , Wang Xuefeng  1 , Liu Jianping  2 , Shen Kunling  3 , Ma Rong  4 , Cui Zhenze  5 , Deng Li  6 , Yan Huimin  3 , Wang Lining  7 , Liu Zhaolan  2 , Li Xinmin  4 , Xu Hua  8 , Jiang Zhiyan  9 , Li Yanning  10 , Huang Yan  5 , Zhang Baoqing  10 , Feng Xiaochun  11 , He Chunhui  6 , Jiang Yonghong  9 , Zhao Xue  1 , Wei Wei  1 , Wang Zi  1
Affiliations
Multicenter Study

Etiology of community-acquired pneumonia in 1500 hospitalized children

Hao Oumei et al. J Med Virol. 2018 Mar.

Abstract

Childhood community-acquired pneumonia (CAP) is a common illness; however, comprehensive studies of hospitalizations for CAP among children in China based on prospective and multicenter data collection are limited. The aim of this investigation was to determine the respiratory pathogens responsible for CAP in hospitalized children. From January to December 2015, oropharyngeal swabs and blood serum were collected from hospitalized children with CAP symptoms ranging in age from 6 months to 14 years at 10 hospitals across China. We used immunofluorescence to detect antibodies for eight respiratory viruses and passive agglutination to detect specific IgM against Mycoplasma pneumoniae (M. pneumoniae). Of 1500 children presenting with CAP, 691 (46.1%) tested positive for at least one pathogen (virus or M. pneumoniae). M. pneumoniae (32.4%) was detected most frequently, followed by respiratory syncytial virus (11.5%), adenovirus (5.0%), influenza A virus (4.1 %), influenza B virus (3.4%), parainfluenza virus types 2 and 3 type (3.1 %), parainfluenza virus type 1 (2.9%), and human metapneumovirus (0.3%). Co-infections were identified in 128 (18.5%) of the 691 cases. These data provide a better understanding of viral etiology and M. pneumoniae in CAP in children between 6 months and 14 years in China. More study of the etiologic investigations that would further aid the management of pneumonia is required. With effective immunization for RSV, ADV, and M. pneumoniae infections, more than one-half of the pneumonia cases in this study could have been prevented.

Keywords: Mycoplasma pneumoniae; children; community-acquired pneumonia; multicenter research; respiratory viruses.

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Figures

Figure 1
Figure 1
Age distribution of respiratory pathogens detected among children ranging from 6 months to 14 yearsof age hospitalized with community‐acquired pneumonia, January‐December, 2015
Figure 2
Figure 2
Seasonal distribution of M. pneumoniae and RSV (A), ADV, IVA, IVB, PIV1, PIV2, PIV3 and HMPV (B) in 691 children hospitalized with community‐acquired pneumonia in 2015
Figure 3
Figure 3
Regional distribution of eight detected viruses and M. pneumoniae in 1500 hospitalized children with community‐acquired pneumonia across China, 2015
See this image and copyright information in PMC

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