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Multicenter Study
. 2017 Oct;13(25):2265-2275.
doi: 10.2217/fon-2017-0246. Epub 2017 Oct 4.

Selecting patients for gastrectomy in metastatic esophago-gastric cancer: clinics and pathology are not enough

Lorenzo Fornaro  1 , Valentina Fanotto  2 , Gianna Musettini  1 , Mario Uccello  3 , Lorenza Rimassa  4 , Caterina Vivaldi  1 , Caterina Fontanella  2 , Francesco Leone  5 , Riccardo Giampieri  6 , Gerardo Rosati  7 , Monica Lencioni  1 , Daniele Santini  8 , Samantha Di Donato  9 , Gianluca Tomasello  10 , Oronzo Brunetti  11 , Filippo Pietrantonio  12 , Francesca Bergamo  13 , Mario Scartozzi  14 , Antonio Avallone  15 , Stefania Eufemia Lutrino  16 , Davide Melisi  17 , Lorenzo Antonuzzo  18 , Antonio Pellegrino  19 , Lorenzo Gerratana  2 , Stefano Cordio  3 , Enrico Vasile  1 , Giuseppe Aprile  2   20
Affiliations
Multicenter Study

Selecting patients for gastrectomy in metastatic esophago-gastric cancer: clinics and pathology are not enough

Lorenzo Fornaro et al. Future Oncol. 2017 Oct.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Future Oncol. 2018 Mar;14(6):577. doi: 10.2217/fon-2017-0246e1. Epub 2018 Feb 14. Future Oncol. 2018. PMID: 29441800 No abstract available.

Abstract

Aim: To evaluate the impact on overall survival (OS) of gastrectomy in asymptomatic metastatic esophago-gastric cancer.

Patients & methods: Five hundred and thirteen patients were included. The role of surgery and other clinico-pathological factors was evaluated by univariate and Cox regression analyses. OS was the primary end point.

Results: Multivariate analysis confirmed that gastrectomy was a predictor of longer OS (p < 0.001), as well as preserved performance status and benefit from first-line chemotherapy. None of the investigated clinico-pathological variables identified preferable candidates for surgery (all p > 0.05).

Conclusion: Palliative gastrectomy might play a role in asymptomatic metastatic esophago-gastric cancer patients with good performance status who received benefit from first-line chemotherapy. Future prospective trials integrating tumor biology among inclusion criteria may help defining the optimal candidates.

Keywords: chemotherapy; metastatic gastric cancer; palliative gastrectomy.

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