Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
- PMID: 28977194
- PMCID: PMC5613718
- DOI: 10.21470/1678-9741-2016-0031
Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
Abstract
Objective: To measure the concentration of cefazolin in the anterior mediastinal adipose tissue of patients undergoing cardiac surgery, determining the variation of cefazolin concentration.
Methods: Two samples of approximately 1g of subcutaneous tissue were collected from 19 patients who underwent surgery in December 2015: the first sample was collected right after sternotomy and the second one, before sternal synthesis with steel wires. Antibiotic dosage was administered through high performance liquid chromatography.
Results: We observed a positive and statistically significant correlation between time 1 and cefazolin concentration (r=0.489 and P=0.039). For time 2 and cefazolin concentration, there was a negative and statistically significant correlation between both variables (r=-0.793 and P<0.001). A negative correlation was also observed between body mass index and cefazolin concentration at time 2 (r=-0.510 and P=0.031). The regression model showed that every 1-minute increase in time 1 corresponded to an increase of 0.240 µg/dL in cefazolin concentration, whereas every 1-minute increase in time 2 corresponded to a reduction of 0.046 µg/dL in cefazolin concentration. As for body mass index, every 1 kg/m2 increase corresponded to a reduction of about 0.510 µg/dL in cefazolin concentration.
Conclusion: There was a positive and significant correlation between the initial time of surgery and cefazolin level in the first dosage. The evaluation of the second dosage showed a negative and significant correlation between cefazolin level and the second time of dosage. The concentration of cefazolin is under the influence of body mass index.
Conflict of interest statement
No conflict of interest.
Similar articles
-
Antibiotic prophylaxis in bariatric surgery with continuous infusion of cefazolin: determination of concentration in adipose tissue.Obes Surg. 2014 Sep;24(9):1487-91. doi: 10.1007/s11695-014-1231-0. Obes Surg. 2014. PMID: 24733372
-
Cefazolin and linezolid penetration into sternal cancellous bone during coronary artery bypass grafting.Eur J Cardiothorac Surg. 2015 Nov;48(5):758-64. doi: 10.1093/ejcts/ezu491. Epub 2014 Dec 18. Eur J Cardiothorac Surg. 2015. PMID: 25527166 Clinical Trial.
-
Pharmacokinetics of cefazolin prophylaxis in obese gravidae at time of cesarean delivery.Am J Obstet Gynecol. 2015 Oct;213(4):541.e1-7. doi: 10.1016/j.ajog.2015.06.034. Epub 2015 Jun 20. Am J Obstet Gynecol. 2015. PMID: 26103528 Free PMC article. Clinical Trial.
-
Quantification of cefazolin in serum and adipose tissue by ultra high performance liquid chromatography-Tandem mass spectrometry (UHPLC-MS/MS): application to a pilot study of obese women undergoing cesarean delivery.J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Sep 15;1031:94-98. doi: 10.1016/j.jchromb.2016.07.032. Epub 2016 Jul 18. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27469905
-
Increased 3-gram cefazolin dosing for cesarean delivery prophylaxis in obese women.Am J Obstet Gynecol. 2015 Sep;213(3):415.e1-8. doi: 10.1016/j.ajog.2015.05.030. Epub 2015 May 21. Am J Obstet Gynecol. 2015. PMID: 26003059 Clinical Trial.
Cited by
-
Population pharmacokinetics and pharmacodynamic target attainment analysis of cefazolin using total and unbound serum concentration in patients with prostatectomy or nephrectomy.Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0026724. doi: 10.1128/aac.00267-24. Epub 2024 May 21. Antimicrob Agents Chemother. 2024. PMID: 38771029 Free PMC article.
-
Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty.Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02114-20. doi: 10.1128/AAC.02114-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33526489 Free PMC article.
References
-
- Braile DM, Gomes WJ. Evolution of cardiovascular surgery. The Brazilian saga. A history of work, pioneering experience and success. Arq Bras Cardiol. 2010;94(2):141–142. - PubMed
-
- Sá MP, Silva DO, Lima EN, Lima RC, Silva FP, Rueda FG, et al. Postoperative mediastinitis in cardiovascular surgery postoperative. Analysis of 1038 consecutive surgeries. Rev Bras Cir Cardiovasc. 2010;25(1):19–24. - PubMed
-
- Engelman R, Shahian D, Shemin R, Guy TS, Bratzler D, Edwards F, et al. Workforce on Evidence-Based Medicine. Society of Thoracic Surgeons The Society of Thoracic Surgeons practice guideline series: antibiotic prophylaxis in cardiac surgery, part II: Antibiotic choice. Ann Thorac Surg. 2007;83(4):1569–1576. - PubMed
-
- Andrews JM. Determination of minimum inhibitory concentrations. J Antimicrob Chemother. 2001;48(Suppl 1):5–16. - PubMed
-
- ANVISA [30/9/2016]. Available from: http://www.anvisa.gov.br/farmacopeiabrasileira/index.htm.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials