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. 2017 Jul-Aug;32(4):239-244.
doi: 10.21470/1678-9741-2016-0031.

Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery

Rodrigo Mezzalira Tchaick  1 , Michel Pompeu Barros Oliveira Sá  1   2 , Fernando Ribeiro de Moraes Figueira  3 , Kilma Coelho Paz  4 , Álvaro Antonio Bandeira Ferraz  5 , Fernando Ribeiro de Moraes Neto  5
Affiliations

Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery

Rodrigo Mezzalira Tchaick et al. Braz J Cardiovasc Surg. 2017 Jul-Aug.

Abstract

Objective: To measure the concentration of cefazolin in the anterior mediastinal adipose tissue of patients undergoing cardiac surgery, determining the variation of cefazolin concentration.

Methods: Two samples of approximately 1g of subcutaneous tissue were collected from 19 patients who underwent surgery in December 2015: the first sample was collected right after sternotomy and the second one, before sternal synthesis with steel wires. Antibiotic dosage was administered through high performance liquid chromatography.

Results: We observed a positive and statistically significant correlation between time 1 and cefazolin concentration (r=0.489 and P=0.039). For time 2 and cefazolin concentration, there was a negative and statistically significant correlation between both variables (r=-0.793 and P<0.001). A negative correlation was also observed between body mass index and cefazolin concentration at time 2 (r=-0.510 and P=0.031). The regression model showed that every 1-minute increase in time 1 corresponded to an increase of 0.240 µg/dL in cefazolin concentration, whereas every 1-minute increase in time 2 corresponded to a reduction of 0.046 µg/dL in cefazolin concentration. As for body mass index, every 1 kg/m2 increase corresponded to a reduction of about 0.510 µg/dL in cefazolin concentration.

Conclusion: There was a positive and significant correlation between the initial time of surgery and cefazolin level in the first dosage. The evaluation of the second dosage showed a negative and significant correlation between cefazolin level and the second time of dosage. The concentration of cefazolin is under the influence of body mass index.

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Conflict of interest statement

No conflict of interest.

Figures

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Fig. 1
Adjustment of the regression models.
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