Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov 1;47(11):1097-1102.
doi: 10.1093/jjco/hyx128.

Estimation of lifetime cumulative incidence and mortality risk of gastric cancer

Yukari Taniyama  1 , Kota Katanoda  2 , Hadrien Charvat  3 , Megumi Hori  2 , Yuko Ohno  1 , Shizuka Sasazuki  3 , Shoichiro Tsugane  4
Affiliations

Estimation of lifetime cumulative incidence and mortality risk of gastric cancer

Yukari Taniyama et al. Jpn J Clin Oncol. .

Abstract

Objective: To estimate cumulative incidence and mortality risk for gastric cancer by risk category.

Methods: Risk was classified into four types according to the presence/absence of Helicobacter pylori infection and chronic atrophic gastritis: in order of lowest to highest risk, Group A: H. pylori(-) and atrophic gastritis(-); Group B: H. pylori(+) and atrophic gastritis(-); Group C:H. pylori(+) and atrophic gastritis(+); and, Group D: H. pylori(-) and atrophic gastritis(+). We used vital statistics for the crude all-cause and crude gastric cancer mortality rates in 2011 and data from population-based cancer registries (the Monitoring of Cancer Incidence in Japan) for gastric cancer incidence in 2011. For relative risk and prevalence, we used the results of a meta-analysis integrating previous studies and data from the Japan Public Health Center-based Prospective Study for the Next Generation, respectively (baseline survey 2011-16). We calculated the crude incidence and mortality rates and estimated the cumulative risk using a life-table method.

Results: The estimated lifetime cumulative incidence risk was 11.4% for men and 5.7% for women. The estimated risk for Groups A, B, C and D was 2.4%, 10.8%, 26.7% and 35.5% for men, and 1.2%, 5.5%, 13.5% and 18.0% for women, respectively. Similarly, the estimated lifetime cumulative mortality risk was 3.9% for men and 1.8% for women. The estimated risk of mortality for Groups A, B, C and D was 0.8%, 3.6%, 9.0% and 12.0% for men, and 0.4%, 1.7%, 4.2% and 5.7% for women, respectively.

Conclusions: Our results may be useful for designing individually tailored prevention programs.

Keywords: Helicobacter pylori; incidence; mortality; risk; stomach neoplasms.

PubMed Disclaimer

References

    1. Recent Cancer Statistics: Center for Cancer Control and Information Services, National Cancer Center http://ganjoho.jp/reg_stat/statistics/stat/summary.html (20 December 2016, date last accessed) (in Japanese).
    1. Kamo K, Katanoda K, Matsuda T, Marugame T, Ajiki W, Sobue T. Lifetime and age-conditional probabilities of developing or dying of cancer in Japan. Jpn J Clin Oncol 2008;38:571–76. - PubMed
    1. Cancer Prevention for Japanese: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center http://epi.ncc.go.jp/en/can_prev/321/189.html (20 December 2016, date last accessed).
    1. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 2007;10:75–83. - PubMed
    1. Nishino Y, Inoue M, Tsuji I, et al. . Tobacco smoking and gastric cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol 2007;36:800–7. - PubMed