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. 2017 May 24;8(37):62358-62370.
doi: 10.18632/oncotarget.18140. eCollection 2017 Sep 22.

Occupational ultraviolet exposure and risk of non-Hodgkin's lymphomas: a meta-analysis

Demin Lu  1   2 , Fei Xu  1 , Kaiming Hu  1 , Li Yin  1 , Huijie Duan  1 , Jiaojiao Zhang  1 , SuZhan Zhang  1   3
Affiliations

Occupational ultraviolet exposure and risk of non-Hodgkin's lymphomas: a meta-analysis

Demin Lu et al. Oncotarget. .

Abstract

Non-Hodgkin lymphoma is a heterogeneous group of lympho-proliferative disorders. We performed a meta-analysis to summarize the available evidence from case-control studies and cohort study on the inconsistent association between occupational sun exposure and the risk of non-Hodgkin lymphoma. We searched PubMed, ISI web of science, the Cochrane Library, EMBASE and reference lists for relevant articles. Study specific odds ratios or relative risk and 95% confidence intervals were pooled by using fixed-effects or random-effects models. Ten case-control studies and one cohort study were included in the meta-analysis. Overall, the pooled odds ratios for occupational ultraviolet exposure and non-Hodgkin lymphoma risk was 1.15(95% confidence intervals: 0.99, 1.32; I2 = 44.4%). Occupational sun exposure was positively associated with the risk of NHL 1.14 (95% confidence intervals: 1.05, 1.23; I2=25.4% p for heterogeneity =0.202) in Caucasian population. Common subtypes of non-Hodgkin lymphoma and ultraviolet exposure had the negative results. The pooled odds ratios was 1.16, (95%confidence intervals: 0.90, 1.50) for T-cell non-Hodgkin lymphoma; 0.79, (95%confidence intervals: 0.61, 1.02) for B-cell non-Hodgkin lymphoma; 1.13, (95%confidence intervals: 0.96, 1.34) for chronic lymphocytic leukemia; 1.25, (95%confidence intervals: 0.95, 1.64) for males; 1.49, (95%confidence intervals: 0.99, 2.25) for females. Data suggested that occupational ultraviolet exposure was a risk factor for non-Hodgkin lymphoma in Caucasian population. While, there had no relationship between occupational ultraviolet exposure and risk of non-Hodgkin lymphoma in general population as well as non-Hodgkin lymphoma common subtypes. Besides, gender specific occupational sun exposure also indicated no association on risk of non-Hodgkin lymphoma.

Keywords: meta-analysis; non-Hodgkin lymphoma; occupational ultraviolet exposure.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flowchart of selection of studies for inclusion in the meta-analysis
Figure 2
Figure 2. Forest plot and summary OR of the association between occupational sun exposure and risk of NHL
Figure 3
Figure 3. Forest plot and summary OR for Caucasian population of occupational sun exposure and risk of NHL
Figure 4
Figure 4
Forest plot and summary OR of T-cell NHL (A), B-cell NHL (B) and CLL (C).
Figure 5
Figure 5
Forest plot and summary OR of male (A) and female (B).
Figure 6
Figure 6
Sensitivity analysis of forest plot and summary OR of nine studies (A) and face to face interview studies (B).
Figure 7
Figure 7. Sensitivity analysis for Caucasian population of occupational sun exposure and risk of NHL
See this image and copyright information in PMC

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References

    1. Zelenetz AD, Abramson JS, Advani RH, Andreadis CB, Byrd JC, Czuczman MS, Fayad L, Forero A, Glenn MJ, Gockerman JP, Gordon LI, Harris NL, Hoppe RT, et al. NCCN Clinical Practice Guidelines in Oncology: non-Hodgkin’s lymphomas. J Natl Compr Canc Netw. 2010;8:288–334. doi: 10.6004/jnccn.2010.0021. - DOI - PubMed
    1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300. doi: 10.3322/caac.20073. - DOI - PubMed
    1. UK cancer incidence. Cancer Research UK 2010 http://www.cancerresearchuk.org/cancer-info/cancerstats/incidence/ Accessed 26 Sep 2013.
    1. Zheng T, Mayne ST, Boyle P, Holford TR, Liu WL, Flannery J. Epidemiology of non-Hodgkin lymphoma in Connecticut. 1935-1988. Cancer. 1992;70:840–49. doi: 10.1002/1097-0142(19920815)70:4<840::AID-CNCR2820700420>3.0.CO;2-I. - DOI - PubMed
    1. Espinosa A, Zock JP, Benavente Y, Boffetta P, Becker N, Brennan P, Cocco P, Foretova L, Maynadié M, Staines A, Nieters A, Kogevinas M, de Sanjose S. Occupational exposure to immunologically active agents and risk for lymphoma: the European Epilymph case-control study. Cancer Epidemiol. 2013;37:378–84. doi: 10.1016/j.canep.2013.02.006. - DOI - PubMed

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