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. 2017 Aug 18;8(40):68916-68927.
doi: 10.18632/oncotarget.20325. eCollection 2017 Sep 15.

Association between essential hypertension and bone mineral density: a systematic review and meta-analysis

Ziliang Ye  1   2 , Haili Lu  1 , Peng Liu  3
Affiliations

Association between essential hypertension and bone mineral density: a systematic review and meta-analysis

Ziliang Ye et al. Oncotarget. .

Abstract

Background: We conducted this systematic review and meta-analysis to evaluate the association between essential hypertension (EH) and bone mineral density (BMD).

Results: 17 articles were included in our meta-analysis, with a total of 39,491 patients. Of these, 13,375 were patients with EH and 26,116 were patients without EH. Meta-analysis results showed that EH can reduce the BMD of the lumbar spine (95% CI: -0.08∼0.01, P=0.006), femoral neck (95% CI: -0.09∼-0.02, p = 0.001), ward's triangle (95% CI: -0.45∼-0.25, p=0.000), femoral intertrochanteric (95% CI: -0.90∼-0.64, p = 0.000), calcaneus (95% CI: -0.31∼-0.18, p = 0.000) and distal forearm (95% CI: -0.09∼-0.03, p = 0.000), but EH cannot reduce the BMD of the femur rotor (95% CI: -0.07∼0.24, p = 0.273). Subgroup analysis showed that EH can reduce the BMD of the lumbar spine (95% CI: -0.11∼-0.03, p = 0.000) and femoral neck (95% CI: -0.11∼-0.07, p = 0.000) in Asian populations. In non-Asian populations, EH can reduce the BMD of the femoral neck (95% CI: 0.04∼0.19, p = 0.002), but cannot reduce the BMD of the lumbar spine (95% CI: -0.04∼0.11, p = 0.346).

Materials and methods: We conducted a systematic review of the published literature on the association of EH and BMD by searching the Cochrane Library, PubMed, EMBASE, CBM, CNKI and VIP databases inception to October 2016. Stata 11.0 software was used for data analysis.

Conclusions: Our meta-analysis suggests that EH can reduce the BMD of the human body, and for different parts of the bone, the degree of reduction is different. In addition, for different regions and populations, the reduction level of BMD is inconsistent.

Keywords: association; bone mineral density; essential hypertension; meta-analysis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors have declared that they have no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram of selection of studies included in the meta-analysis
Figure 2
Figure 2. Forest plot of bone mineral density of lumbar spine and femur rotor with essential hypertension
Figure 3
Figure 3. Forest plot of bone mineral density of lumbar spine with essential hypertension (Asian and non-Asian)
Figure 4
Figure 4. Forest plot of bone mineral density of femoral neck and Ward's triangle with essential hypertension
Figure 5
Figure 5. Forest plot of bone mineral density of femoral neck with essential hypertension (Asian and non-Asian)
Figure 6
Figure 6. Forest plot of bone mineral density of femoral intertrochanteric, calcaneus, and distal forearm with essential hypertension
Figure 7
Figure 7. Funnel plot of bone mineral density of lumbar spine with essential hypertension
Figure 8
Figure 8. Funnel plot of bone mineral density of femoral neck with essential hypertension
Figure 9
Figure 9. Funnel plot of bone mineral density at Ward's triangle with essential hypertension
See this image and copyright information in PMC

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