[2016 revision of the WHO classification of lymphoid neoplasms]

Abstract

The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms have been published in "Blood" as a review form. A major revision is being published that will be an update of the current fourth edition and not a truly new fifth edition. Because it is considered a part of the fourth edition, while some provisional entities will be promoted to definite entities and a small number of new provisional entities added, there will be no new definite entities. As with the 2001 and 2008 classifications, an all-important Clinical Advisory Committee meeting was held to obtain the advice and consent of clinical hematologists/oncologists and other physicians critical to the revision. The classification maintains the goals of helping to identify homogeneous groups of well-defined entities and facilitating the recognition of uncommon diseases that require further clarification. Some provisional or variant entities; EBV-positive large B-cell lymphoma, elderly and Pediatric follicular lymphoma focused on the age of onset, in situ lesions, and gray zone lymphomas, recognized in the 2008 WHO classification, were revised. This will review the major areas in mature B-cell lymphoid and mature T/NK-cell lymphoid neoplasms and Hodgkin lymphoma where changes from the 2008 WHO classification.

Keywords: 2016 revision; Lymphoid neoplasms; Lymphoma; WHO classification.