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. 2017 Sep 11:11:2685-2695.
doi: 10.2147/DDDT.S145716. eCollection 2017.

Metal organic frameworks as a drug delivery system for flurbiprofen

Muder Al Haydar  1   2 , Hussein Rasool Abid  3   4 , Bruce Sunderland  2 , Shaobin Wang  5   6
Affiliations

Metal organic frameworks as a drug delivery system for flurbiprofen

Muder Al Haydar et al. Drug Des Devel Ther. .

Abstract

Background: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible.

Purpose: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employed for FBP delivery.

Patients and methods: A sample of 50 mg of each MOF was mixed and stirred for 24 h with 10 mL of 5 mg FBP in acetonitrile (40%) in a sealed container. The supernatant of the mixture after centrifuging was analyzed by high-performance liquid chromatography to determine the loaded quantity of FBP on the MOF. The overnight-dried solid material after centrifuging the mixture was analyzed for loading percent using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance, and FBP release profile.

Results: The loading values of FBP were achieved at 10.0%±1%, 20%±0.8%, 37%±2.3%, and 46%±3.1% on Ca-MOF, Fe-MIL-53, Fe-MIL-101, and Fe-MIL-100, respectively. The FBP release profiles were investigated in a phosphate buffer solution at pH 7.4. The total release of the FBP after 2 days was obtained at 72.9, 75.2, 78.3, and 90.3% for Ca-MOF, Fe-MIL-100, Fe-MIL-53, and Fe-MIL-101, respectively.

Conclusion: The MOFs are shown to be a promising drug delivery option for FBP with a significant loading percent and relatively prolonged drug release.

Keywords: FBP; drug loading; drug release; porous MOF.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flurbiprofen chemical structure.
Figure 2
Figure 2
X-ray powder diffraction of (A) Ca-MOF and FBP@Ca-MOF, (B) Fe-MIL-53 and FBP@Fe-MIL-53, (C) Fe-MIL-101 and FBP@Fe-MIL-101, (D) Fe-MIL-100 and FBP@Fe-MIL-100. Abbreviations: FBP, flurbiprofen; MOF, metal organic framework.
Figure 3
Figure 3
Fourier-transform infrared spectra of (A) Ca-MOF (red) and FBP@Ca-MOF (blue), (B) Fe-MIL-100 (red) and FBP@Fe-MIL-100 (blue), (C) Fe-MIL-101 (red) and FBP@Fe-MIL-101 (blue) and (D) Fe-MIL-53 (red) and FBP@Fe-MIL-53 (blue). Note: FBP spectrum (black). Abbreviations: FBP, flurbiprofen; MOF, metal organic framework.
Figure 4
Figure 4
Scanning electron microscopy images of (A) Ca-MOF, (A¯) FBP@Ca-MOF, (B) Fe-MIL-53, (B¯) FBP@Fe-MIL-53, (C) Fe-MIL-101, (C¯) FP@Fe-MIL-101, (D) Fe-MIL-100, and (D¯) FBP@Fe-MIL-100. Abbreviations: FBP, flurbiprofen; MOF, metal organic framework.
Figure 5
Figure 5
FBP release profiles in 50 mmol phosphate buffer solution at pH 7.4 and 37°C. Abbreviations: FBP, flurbiprofen; MOF, metal organic framework.
See this image and copyright information in PMC

References

    1. Vallet-Regí M, Balas F, Arcos D. Mesoporous materials for drug delivery. Angewandte Chemie International Edition. 2007;46(40):7548–7558. - PubMed
    1. Huxford RC, Della Rocca J, Lin W. Metal–organic frameworks as potential drug carriers. Current Opinion in Chemical Biology. 2010;14(2):262–268. - PMC - PubMed
    1. Rosi NL, Eddaoudi M, Kim J, O’Keeffe M, Yaghi OM. Advances in the chemistry of metal-organic frameworks. Cryst Eng Comm. 2002;4(68):401–404.
    1. Meek ST, Greathouse JA, Allendorf MD. Metal-organic frameworks: a rapidly growing class of versatile nanoporous materials. Adv Mater. 2011;23(2):249–267. - PubMed
    1. Valtchev V, Tosheva L. Porous nanosized particles: preparation, properties, and applications. Chemical Reviews. 2013;113(8):6734–6760. - PubMed

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