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. 2017 Oct 1;58(12):4990-4996.
doi: 10.1167/iovs.17-22219.

Impact of Myopia on Corneal Biomechanics in Glaucoma and Nonglaucoma Patients

Sunee Chansangpetch  1   2 , Rawiphan Panpruk  1 , Anita Manassakorn  1 , Visanee Tantisevi  1 , Prin Rojanapongpun  1 , Cameron P Hurst  3 , Shan C Lin  2
Affiliations

Impact of Myopia on Corneal Biomechanics in Glaucoma and Nonglaucoma Patients

Sunee Chansangpetch et al. Invest Ophthalmol Vis Sci. .

Abstract

Purpose: We evaluated the impact of myopia on corneal biomechanical properties in primary open-angle glaucoma (POAG) and nonglaucoma patients, and the effect of modification of glaucoma on myopic eyes.

Methods: This cross-sectional study included 66 POAG eyes (33 myopia, 33 nonmyopia) and 66 normal eyes (33 myopia, 33 nonmyopia). Seven corneal biomechanical parameters were measured by ultra-high-speed Scheimpflug imaging, including corneal deformation amplitude (CDA), inward/outward corneal applanation length (ICA, OCA), inward/outward corneal velocity (ICV, OCV), radius, and peak distance (PD).

Results: Mean age (SD) of the 65 male (49%) and 67 female (51%) patients was 59 (9.82) years. Myopia was associated with significantly higher CDA (adjusted effect = 0.104, P = 0.001) and lower OCV (adjusted effect = -0.105, P < 0.001) in the POAG group. Within the nonglaucoma group, myopic eyes had a significantly lower OCV (adjusted effect = -0.086, P < 0.001) and higher CDA (adjusted effect = 0.079, P = 0.001). All parameters except PD suggested that glaucoma modified the effect of myopia on corneal biomechanics. Percentage differences in the adjusted myopic effect between POAG and nonglaucoma patients was 31.65, 27.27, 31.65, 50.00, 22.09, and 60.49 for CDA, ICA, OCA, ICV, OCV, and radius, respectively.

Conclusions: Myopia had a significant impact on corneal biomechanical properties in the POAG and nonglaucoma groups. The differences in corneal biomechanical parameters suggest that myopia is correlated with significantly lower ocular rigidity. POAG may enhance the effects of myopia on most of these parameters.

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Figures

Figure
Figure
Diagram illustrates each state of corneal deformation during Corvis ST measurement, and the parameters: Top: First flattened state or the first applanation point. Middle: Maximum deformation state or point of highest concavity. Bottom: Second flattened state or second applanation point.
See this image and copyright information in PMC

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