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Case Reports
. 2018 Jun;12(2):274-278.
doi: 10.1007/s12105-017-0855-5. Epub 2017 Oct 4.

Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications

Bin Xu  1 , Ruth Aryeequaye  1 , Lu Wang  1 , Nora Katabi  2
Affiliations
Case Reports

Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications

Bin Xu et al. Head Neck Pathol. 2018 Jun.

Abstract

Secretory carcinoma (SC) is a recently described salivary gland carcinoma with characteristic ETV6-NTRK3 fusion. In this case report, we described a SC of the maxillary sinus that underwent high grade transformation in a 61-year-old patient. The diagnosis was confirmed by the presence of ETV6 translocation. Within the sinonasal tract, SC is an important differential diagnosis especially of sinonasal adenocarcinoma, non-intestinal type (non-ITAC), as these two entities bears histologic and immunophenotypic similarity. Distinction between these two tumors can be challenging based on the morphology alone and may require additional immunohistochemical and molecular studies. It is important to recognize that SC can occur in the sinonasal tract as correctly diagnosing SC may be prognostic relevant and may provide new targeted therapeutic avenues for these patients.

Keywords: ETV6-NTRK3 fusion; High grade transformation; Secretory carcinoma; Sinonasal non-intestinal type adenocarcinoma.

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Conflict of interest statement

Conflict of interest

All authors declare that he/she has no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Figures

Fig. 1
Fig. 1
Secretory carcinoma (SC) of maxillary sinus (hematoxylin and eosin, a ×100 and b ×400) with high grade transformation (c ×200, d ×400). The maxillectomy contained an infiltrative carcinoma with predominant microcystic pattern. Eosinophilic material was noted within the cystic lumen. The tumor cells were relatively uniform with eosinophilic to clear vacuolated cytoplasm, oval nuclei, vesicular chromatin, and small nucleoli. Areas of solid growth with comedo type necrosis (Ne) and elevated mitotic activity were present multifocally within this tumor, diagnostic of high grade transformation. e–g Immunophemotypically, this tumor was positive for S100, mammaglobin and gross cystic disease fluid protein-15 (GCDFP-15). h Fluorescence in situ hybridization (FISH) demonstrated ETV6 rearrangement (red and green arrows) using ETV6 break-apart probe
See this image and copyright information in PMC

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