Review

. 2017;31(9):1168-1176.

doi: 10.1080/02699052.2016.1274779.

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Ibolja Cernak¹, Donald G Stein², Gregory A Elder^{3

4}, Stephn Ahlers⁵, Kenneth Curley^{6

7}, Ralph G DePalma⁸, John Duda⁹, Milos Ikonomovic¹⁰, Grant L Iverson¹¹, Firas Kobeissy¹², Vassilis E Koliatsos¹³, Michael J Leggieri Jr¹⁴, Anthony M Pacifico¹⁵, Douglas H Smith¹⁶, Raymond Swanson¹⁷, Floyd J Thompson¹⁸, Frank C Tortella¹⁹

Affiliations

¹ a Military and Veterans' Clinical Rehabilitation Research, Faculty of Rehabilitation Medicine , University of Alberta , Edmonton , Alberta , Canada.
² b Emory School of Medicine , Department of Emergency Medicine Brain Research Laboratory , Atlanta , Georgia , USA.
³ c James J. Peters VA Medical Center , Bronx , NY , USA.
⁴ d Icahn School of Medicine at Mount Sinai , New York , New York , USA.
⁵ e Operational and Undersea Medicine, Naval Medical Research Center , Silver Spring , MD , USA.
⁶ f Iatrikos Research and Development Strategies, LLC , Tampa , FL , USA.
⁷ g Department of Surgery , Uniformed Services University of the Health Sciences , Bethesda , MD , USA.
⁸ h VA ORD & Department of Surgery , Uniformed Services University of the Health Sciences, Office of Research and Development , Washington , DC , USA.
⁹ i Parkinson's Disease Research, Education and Clinical Center, Philadelphia VA Medical Center; and Department of Neurology , Perelman School of Medicine, University of Pennsylvania , Philadelphia , PA , USA.
¹⁰ j Department of Neurology , University of Pittsburgh , Pittsburgh , PA , USA.
¹¹ k Neuropsychology Outcome Assessment Laboratory, Department of Physical Medicine and Rehabilitation , Harvard Medical School , Boston , MA , USA.
¹² l Psychoproteomics and Nanotechnology Research Center, Department of Psychiatry , The Evelyn F and William L. McKnight Brain Institute, University of Florida , Gainesville , FL , USA.
¹³ m Department of Pathology (Neuropathology) and Neurology , Johns Hopkins School of Medicine , Baltimore , MD , USA.
¹⁴ n DoD Blast Injury Research Program Coordinating Office, U.S. Army Medical Research and Materiel Command , Ft Detrick , MD , USA.
¹⁵ o Alzheimer's and Epilepsy Research Programs, Congressionally Directed Medical Research Programs; US Department of Health and Human Services , Telemedicine and Advanced Technology Research Center , Fort Detrick , MD , USA.
¹⁶ p The Robert A. Groff Professor of Neurosurgery/Research and Education, Department of Neurosurgery/PENN's Center for Brain Injury and Repair , University of Pennsylvania , Philadelphia , PA , USA.
¹⁷ q Department of Neurology , University of California San Francisco; and Neurology Service, SFVAMC , San Francisco , CA , USA.
¹⁸ r Brain Rehabilitation Research Center, Malcom Randall VAMC; Physiological Sciences and Professor Emeritus, Neuroscience, University of Florida , Gainesville , FL , USA.
¹⁹ s Branch of Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research ; Silver Spring , MD , USA.

PMID: 28981339
PMCID: PMC9351990
DOI: 10.1080/02699052.2016.1274779

Review

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Ibolja Cernak et al. Brain Inj. 2017.

. 2017;31(9):1168-1176.

doi: 10.1080/02699052.2016.1274779.

Authors

Affiliations

¹ a Military and Veterans' Clinical Rehabilitation Research, Faculty of Rehabilitation Medicine , University of Alberta , Edmonton , Alberta , Canada.
² b Emory School of Medicine , Department of Emergency Medicine Brain Research Laboratory , Atlanta , Georgia , USA.
³ c James J. Peters VA Medical Center , Bronx , NY , USA.
⁴ d Icahn School of Medicine at Mount Sinai , New York , New York , USA.
⁵ e Operational and Undersea Medicine, Naval Medical Research Center , Silver Spring , MD , USA.
⁶ f Iatrikos Research and Development Strategies, LLC , Tampa , FL , USA.
⁷ g Department of Surgery , Uniformed Services University of the Health Sciences , Bethesda , MD , USA.
⁸ h VA ORD & Department of Surgery , Uniformed Services University of the Health Sciences, Office of Research and Development , Washington , DC , USA.
⁹ i Parkinson's Disease Research, Education and Clinical Center, Philadelphia VA Medical Center; and Department of Neurology , Perelman School of Medicine, University of Pennsylvania , Philadelphia , PA , USA.
¹⁰ j Department of Neurology , University of Pittsburgh , Pittsburgh , PA , USA.
¹¹ k Neuropsychology Outcome Assessment Laboratory, Department of Physical Medicine and Rehabilitation , Harvard Medical School , Boston , MA , USA.
¹² l Psychoproteomics and Nanotechnology Research Center, Department of Psychiatry , The Evelyn F and William L. McKnight Brain Institute, University of Florida , Gainesville , FL , USA.
¹³ m Department of Pathology (Neuropathology) and Neurology , Johns Hopkins School of Medicine , Baltimore , MD , USA.
¹⁴ n DoD Blast Injury Research Program Coordinating Office, U.S. Army Medical Research and Materiel Command , Ft Detrick , MD , USA.
¹⁵ o Alzheimer's and Epilepsy Research Programs, Congressionally Directed Medical Research Programs; US Department of Health and Human Services , Telemedicine and Advanced Technology Research Center , Fort Detrick , MD , USA.
¹⁶ p The Robert A. Groff Professor of Neurosurgery/Research and Education, Department of Neurosurgery/PENN's Center for Brain Injury and Repair , University of Pennsylvania , Philadelphia , PA , USA.
¹⁷ q Department of Neurology , University of California San Francisco; and Neurology Service, SFVAMC , San Francisco , CA , USA.
¹⁸ r Brain Rehabilitation Research Center, Malcom Randall VAMC; Physiological Sciences and Professor Emeritus, Neuroscience, University of Florida , Gainesville , FL , USA.
¹⁹ s Branch of Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research ; Silver Spring , MD , USA.

PMID: 28981339
PMCID: PMC9351990
DOI: 10.1080/02699052.2016.1274779

Abstract

As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.

Keywords: United States Department of Veterans Affairs; blast-induced neurotrauma; conference; experimental models; preclinical research; traumatic brain injury.

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Conflict of interest statement

Declaration of Interest

The authors report no declarations of interest.

Figures

**Figure 1.**
Number of articles using (A) rat or (B) mouse TBI or BINT models published between 2008 and the first half of 2016.

**Figure 2.**
Number of articles using (A) rat or (B) mouse TBI or BINT models published between 1999 and 2007.

See this image and copyright information in PMC

References

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1. Holtkamp MD, Grimes J, Ling G. Concussion in the military: an evidence-base review of mTBI in US military personnel focused on posttraumatic headache. Curr Pain Headache Rep. 2016;20(6):37. - PubMed
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Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Affiliations

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials