Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1988 Apr;25(4):433-8.
doi: 10.1111/j.1365-2125.1988.tb03326.x.

Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists

O J Robb  1 , J Webster, J C Petrie, J D Harry, J Young
Affiliations
Clinical Trial

Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists

O J Robb et al. Br J Clin Pharmacol. 1988 Apr.

Abstract

1. The selective beta 2-adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1-adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2-selective antagonism does not play a role in the hypotensive action of beta-adrenoceptor antagonists.

PubMed Disclaimer

References

    1. J Pharm Pharmacol. 1981 Apr;33(4):223-5 - PubMed
    1. Br J Clin Pharmacol. 1981 Aug;12(2):211-4 - PubMed
    1. J Cardiovasc Pharmacol. 1983 May-Jun;5(3):430-7 - PubMed
    1. N Engl J Med. 1983 Dec 8;309(23):1414-9 - PubMed
    1. Br Med J (Clin Res Ed). 1986 Mar 15;292(6522):746-50 - PubMed

Publication types