Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Sep 21:4:152.
doi: 10.3389/fmed.2017.00152. eCollection 2017.

Anti-IgE Treatment for Disorders Other Than Asthma

Jeffrey Stokes  1
Affiliations
Review

Anti-IgE Treatment for Disorders Other Than Asthma

Jeffrey Stokes. Front Med (Lausanne). .

Abstract

Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Currently, omalizumab is approved for the treatment of both allergic asthma and chronic spontaneous urticaria. Since IgE plays a critical role in other allergic diseases, anti-IgE therapy has been evaluated in other allergic diseases in small clinical trials and case reports. Omalizumab has demonstrated efficacy in treating allergic rhinitis, atopic dermatitis, physical urticarias, mast cell disorders, food allergy, and other allergic diseases. In addition, the use of omalizumab with conventional allergen immunotherapy improves both safety and effectiveness.

Keywords: allergy; asthma; immunotherapy; omalizumab; urticaria.

PubMed Disclaimer

References

    1. Lynch NR, Hagel IA, Palenque ME, Di Prisco MC, Escudero JE, Corao LA, et al. Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol (1998) 101:217.10.1016/S0091-6749(98)70386-0 - DOI - PubMed
    1. Schroeder HW, Jr, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol (2010) 125:S41–52.10.1016/j.jaci.2009.09.046 - DOI - PMC - PubMed
    1. Vercelli D. Immunobiology of IgE. 7th ed In: Adkinson N, Bochner BS, Busse WW, et al., editors. Middleton’s Allergy: Principles and Practice. Mosby Elsevier; (2009).
    1. Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol (2010) 125:S73–80.10.1016/j.jaci.2009.11.017 - DOI - PMC - PubMed
    1. Geha RS, Jabara HH, Brodeur SR. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol (2003) 3:721.10.1038/nri1181 - DOI - PubMed