Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Dec;83(12):2595-2598.
doi: 10.1111/bcp.13432. Epub 2017 Oct 6.

Free dug concentrations in pregnancy: Bound to measure unbound?

Stein Schalkwijk  1   2 , Rick Greupink  2 , David Burger  1
Affiliations
Editorial

Free dug concentrations in pregnancy: Bound to measure unbound?

Stein Schalkwijk et al. Br J Clin Pharmacol. 2017 Dec.
No abstract available

Keywords: albumin; antiretrovirals; pharmacokinetics; pregnancy; protein binding.

PubMed Disclaimer

Comment on

References

    1. Marzolini C, Decosterd L, Winterfeld U, Tissot F, Francini K, Buclin T, et al Free and total plasma concentrations of elvitegravir/cobicistat during pregnancy and postpartum: a case report. Br J Clin Pharmacol 2017; 83: 2835–2838. - PMC - PubMed
    1. Harris NS, Fowler MG, Sansom SL, Ruffo N, Lampe MA. Use of enhanced perinatal human immunodeficiency virus surveillance methods to assess antiretroviral use and perinatal human immunodeficiency virus transmission in the United States, 1999–2001. Am J Obstet Gynecol 2007; 197 (3 Suppl): S33–S41. - PubMed
    1. Townsend CL, Byrne L, Cortina‐Borja M, Thorne C, de Ruiter A, Lyall H, et al Earlier initiation of ART and further decline in mother‐to‐child HIV transmission rates, 2000‐2011. AIDS 2014; 28: 1049–1057. - PubMed
    1. Anderson GD. Pregnancy‐induced changes in pharmacokinetics: a mechanistic‐based approach. Clin Pharmacokinet 2005; 44: 989–1008. - PubMed
    1. Metsu D, Toutain PL, Chatelut E, Delobel P, Gandia P. Antiretroviral unbound concentration during pregnancy: piece of interest in the puzzle? J Antimicrob Chemother 2017; 72: 2407–2409. - PubMed

LinkOut - more resources