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. 2017 Sep 15;54(9):735-738.
doi: 10.1007/s13312-017-1164-5.

Pediatric Rhabdomyosarcoma in India: A Single-center Experience

Deepak Bansal  1 , Anirban Das, Amita Trehan, Rakesh Kapoor, Naresh K Panda, Radhika Srinivasan, Naresh K Panda, Radhika Srinivasan, Nandita Kakkar, Kushaljit S Sodhi, Akshay K Saxena, Katragadda Lakshmi Narasimha Rao
Affiliations

Pediatric Rhabdomyosarcoma in India: A Single-center Experience

Deepak Bansal et al. Indian Pediatr. .

Abstract

Objective: Analyze the profile and outcome of children with rhabdomyosarcoma from a pediatric-oncology unit.

Design: Retrospective analysis of case records over 23 years (1990-2012).

Setting: Government-run, tertiary-care, university hospital in Northern India.

Participants: 159 children (<12-years) with a diagnosis of rhabdomyosarcoma were enrolled. The median age was 4 years; 13% were infants.

Main outcome measure: Five-year event free survival.

Results: The median symptom interval was 2-months. Head and neck region was the most frequent site (44%), followed by tumors in the extremity (15.7%). The majority (67%) of the tumors were located at 'unfavorable' sites; 68% were >5 cm in size. The most frequent (58%) pathological subtype was embryonal. Treatment was based on the 'Intergroup Rhabdomyosarcoma Study (IRS) Group' risk-stratification. 33% were 'low-risk' children, 11% were 'high-risk'. Treatment-refusal (18%) and abandonment (33%) were major impediments. The median ± SE five-year event free survival of those taking treatment was 43.6 ± 6%.

Conclusion: Large sized tumors, tumors at unfavorable locations, and treatment refusal/abandonment contributed to inferior outcome in children with rhabdomyosarcoma.

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