Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;114(3):306-8.
doi: 10.1007/BF00405839.

Antiproliferative effects of somatostatin and the somatostatin analog SMS 201-995 on three human breast cancer cell lines

G Scambia  1 , P B Panici, G Baiocchi, L Perrone, S Iacobelli, S Mancuso
Affiliations

Antiproliferative effects of somatostatin and the somatostatin analog SMS 201-995 on three human breast cancer cell lines

G Scambia et al. J Cancer Res Clin Oncol. 1988.

Abstract

The antiproliferative effect of somatostatin and the somatostatin analog SMS 201-995 on three human breast cancer cell lines (CG5, T 47 D, and ZR 75-1) is reported. Both peptides markedly inhibited CG5 cell growth with a maximal inhibition of about 40% as compared with control cells. The antiproliferative effect of somatostatin on T 47 D and ZR 75-1 cells was much less evident. These results suggest that somatostatin is a peptide inhibitory factor for human breast cancer cells. Possible therapeutic implications of these findings are still to be investigated.

PubMed Disclaimer

References

    1. Del Pozo E, Nenfeld M, Schluter K, Tortora F, Clarenbach P, Bieder E, Wendel L, Nuesch A, Marbach P, Cramer M, Kerp L (1986) Endocrine profile of a long-acting somatostatin derivative SMS 201-995. Study in normal volunteers following subcutaneous administration. Acta Endocrinol 11:433–439 - PubMed
    1. Fockens JA, Henkelman MS, Furkkink JF, Blankestein MA, Klijn JGM (1986) Combined effects of buserelin estradiol and tamoxifen on the growth of MCF-7 human breast cancer cells in vitro. Biochem Biophys Res Commun 140:550–556 - PubMed
    1. Ghirlanda G, Uccioli L, Perri F, Altomonte L, Bertoli A, Manna R, Frati L, Greco AV (1983) Epidermal growth factor, somatostatin and psoriasis. Lancet I:65 - PubMed
    1. Hierowski MT, Liebow C, Du Sapin K, Schally AV (1985) Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA Pa Ca-2 cell line. FEBS Lett 179:252–256 - PubMed
    1. Iversen OH (1981) The chalones. In: Baserga R (ed) Tissue growth factors. Springer, Berlin Heidelberg New York, pp 491–503

LinkOut - more resources