Malaria in pregnancy: the relevance of animal models for vaccine development

Abstract

Malaria during pregnancy due to Plasmodium falciparum or P. vivax is a major public health problem in endemic areas, with P. falciparum causing the greatest burden of disease. Increasing resistance of parasites and mosquitoes to existing tools, such as preventive antimalarial treatments and insecticide-treated bed nets respectively, is eroding the partial protection that they offer to pregnant women. Thus, development of effective vaccines against malaria during pregnancy is an urgent priority. Relevant animal models that recapitulate key features of the pathophysiology and immunology of malaria in pregnant women could be used to accelerate vaccine development. This review summarizes available rodent and nonhuman primate models of malaria in pregnancy, and discusses their suitability for studies of biologics intended to prevent or treat malaria in this vulnerable population.

FIGURE 1 |

Schematic summarizing different malarial parasites and current knowledge of infected erythrocytes (IEs) and mechanisms in humans, nonhuman primates, and rodent models of malaria in pregnancy. For more details, see Table 1.

FIGURE 2 |

Illustration demonstrating key differences in placental anatomy between humans and mice.