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Review
. 2017 Dec:37:59-64.
doi: 10.1016/j.coph.2017.08.011. Epub 2017 Oct 3.

Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis

Paul W Caton  1 , Elizabeth A Evans  2 , Michael P Philpott  3 , Rosalind F Hannen  3
Affiliations
Review

Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis

Paul W Caton et al. Curr Opin Pharmacol. 2017 Dec.

Abstract

Prevalence of obesity and related complications such as type 2 diabetes (T2D) has increased dramatically in recent decades. Metabolic complications of obesity arise in part due to subcutaneous adipose tissue (SAT) dysfunction. However, it is currently unclear why some obese individuals develop insulin resistance and T2D and others do not. In this review, we discuss the role of the skin in regulating SAT function, and whether presence of inflammatory skin diseases such as psoriasis represent a novel risk mechanism mediating development of obesity-related complications.

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