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Meta-Analysis
. 2017 Oct 6;18(1):111.
doi: 10.1186/s12881-017-0475-7.

Gender differences in the prevalence of congenital heart disease in Down's syndrome: a brief meta-analysis

Tereza Cristina Pinheiro Diogenes  1   2 , Felipe Alves Mourato  3   4   5 , José Luiz de Lima Filho  2 , Sandra da Silva Mattos  1   2
Affiliations
Meta-Analysis

Gender differences in the prevalence of congenital heart disease in Down's syndrome: a brief meta-analysis

Tereza Cristina Pinheiro Diogenes et al. BMC Med Genet. .

Abstract

Background: Down's syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40-60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them.

Methods: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.

Results: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.

Conclusion: CHD, particularly AVSD, are more common in the female gender of Down's syndrome patients.

Keywords: Congenital heart disease; Down; Gender; Meta-analysis; Systematic review.

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Figures

Fig. 1
Fig. 1
Flow chart of eligible studies for meta-analysis
Fig. 2
Fig. 2
Meta-analysis of all CHD and AVSD by gender in Down syndrome. IC-Interval of confidence. OR-Odds Ratio. a – OR meta-analysis of all CHD in Down syndrome by gender. b – OR meta-analysis of AVSD in Down syndrome by gender
Fig. 3
Fig. 3
Meta-analysis of ASD and VSD by gender in Down syndrome. IC-Interval of confidence. OR-Odds Ratio. a – OR meta-analysis of ASD in Down syndrome by gender. b – OR meta-analysis of VSD in Down syndrome by gender
Fig. 4
Fig. 4
Meta-analysis of PDA and TOF by gender in Down syndrome. IC-Interval of confidence. OR-Odds Ratio. a – OR meta-analysis of PDA in Down syndrome by gender. b – OR meta-analysis of TOF in Down syndrome by gender
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