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. 2017 Oct 6;7(1):100.
doi: 10.1186/s13613-017-0324-z.

Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort

Nuttapol Rittayamai  1   2   3 , François Beloncle  1   2   4 , Ewan C Goligher  1   5   6   7 , Lu Chen  1   2 , Jordi Mancebo  8   9 , Jean-Christophe M Richard  10   11 , Laurent Brochard  12   13
Affiliations

Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort

Nuttapol Rittayamai et al. Ann Intensive Care. .

Abstract

Background: In pressure-controlled (PC) ventilation, tidal volume (V T) and transpulmonary pressure (P L ) result from the addition of ventilator pressure and the patient's inspiratory effort. PC modes can be classified into fully, partially, and non-synchronized modes, and the degree of synchronization may result in different V T and P L despite identical ventilator settings. This study assessed the effects of three PC modes on V T, P L , inspiratory effort (esophageal pressure-time product, PTPes), and airway occlusion pressure, P 0.1. We also assessed whether P 0.1 can be used for evaluating patient effort.

Methods: Prospective, randomized, crossover physiologic study performed in 14 spontaneously breathing mechanically ventilated patients recovering from acute respiratory failure (1 subsequently withdrew). PC modes were fully (PC-CMV), partially (PC-SIMV), and non-synchronized (PC-IMV using airway pressure release ventilation) and were applied randomly; driving pressure, inspiratory time, and set respiratory rate being similar for all modes. Airway, esophageal pressure, P 0.1, airflow, gas exchange, and hemodynamics were recorded.

Results: V T was significantly lower during PC-IMV as compared with PC-SIMV and PC-CMV (387 ± 105 vs 458 ± 134 vs 482 ± 108 mL, respectively; p < 0.05). Maximal P L was also significantly lower (13.3 ± 4.9 vs 15.3 ± 5.7 vs 15.5 ± 5.2 cmH2O, respectively; p < 0.05), but PTPes was significantly higher in PC-IMV (215.6 ± 154.3 vs 150.0 ± 102.4 vs 130.9 ± 101.8 cmH2O × s × min-1, respectively; p < 0.05), with no differences in gas exchange and hemodynamic variables. PTPes increased by more than 15% in 10 patients and by more than 50% in 5 patients. An increased P 0.1 could identify high levels of PTPes.

Conclusions: Non-synchronized PC mode lowers V T and P L in comparison with more synchronized modes in spontaneously breathing patients but can increase patient effort and may need specific adjustments. Clinical Trial Registration Clinicaltrial.gov # NCT02071277.

Keywords: Airway pressure release ventilation; Lung-protective ventilation; Spontaneous ventilation; Transpulmonary pressure; Ventilator-induced lung injury.

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Figures

Fig. 1
Fig. 1
Tracings of airway pressure, esophageal pressure, flow, transpulmonary pressure, and tidal volume during each pressure-controlled mode of ventilation. The degree of inspiratory synchronization leads to varying in transpulmonary pressure and tidal volume. PC-CMV pressure-controlled continuous mandatory ventilation, PC-SIMV pressure-controlled synchronized intermittent mandatory ventilation, PC-IMV pressure-controlled intermittent mandatory ventilation
Fig. 2
Fig. 2
Tidal volume and tidal volume variability during fully, partially, and non inspiratory synchronized pressure-controlled modes (*p < 0.05; PC-IMV vs PC-CMV and # p < 0.05; PC-IMV vs PC-SIMV). PC-CMV pressure-controlled continuous mandatory ventilation, PC-SIMV pressure-controlled synchronized intermittent mandatory ventilation, PC-IMV pressure-controlled intermittent mandatory ventilation
Fig. 3
Fig. 3
Maximal, mean, and minimum transpulmonary pressure (P L) during the three pressure-controlled modes of ventilation. PC-CMV pressure-controlled continuous mandatory ventilation, PC-SIMV pressure-controlled synchronized intermittent mandatory ventilation, PC-IMV pressure-controlled intermittent mandatory ventilation
See this image and copyright information in PMC

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