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. 1988 Jul 9;2(8602):72-4.
doi: 10.1016/s0140-6736(88)90006-2.

Enhanced tumour necrosis factor and interleukin-1 in fulminant hepatic failure

Y Muto  1 , K T Nouri-Aria, A Meager, G J Alexander, A L Eddleston, R Williams
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Enhanced tumour necrosis factor and interleukin-1 in fulminant hepatic failure

Y Muto et al. Lancet. .

Abstract

Sepsis and endotoxaemia are common in fulminant hepatic failure (FHF) and may contribute to multisystem disease in such patients. Tumour necrosis factor (TNF) is a probable mediator of endotoxic shock and infusion of this monokine into animals causes multi-organ failure that shares features with FHF. In patients with FHF, TNF production was increased and correlated closely with activity of interleukin-1, another cytokine that is released by monocytes/macrophages in response to infection and endotoxin and is produced in increased quantities in FHF. Interleukin-2 activity was impaired in FHF and correlated negatively with TNF production.

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