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. 2017 Oct;25(4):968-975.
doi: 10.1016/j.jfda.2016.11.002. Epub 2016 Dec 5.

Exploration of ethyl anthranilate-loaded monolithic matrix-type prophylactic polymeric patch

Johirul Islam  1   2 , Kamaruz Zaman  2 , Srijita Chakrabarti  1 , Nilutpal Sharma Bora  1 , Manash Pratim Pathak  1 , Santa Mandal  1 , Julfikar Ali Junejo  2 , Pronobesh Chattopadhyay  1
Affiliations

Exploration of ethyl anthranilate-loaded monolithic matrix-type prophylactic polymeric patch

Johirul Islam et al. J Food Drug Anal. 2017 Oct.

Abstract

Compromised stability of pharmaceutical formulations loaded with volatiles is a serious problem associated with devices designed to deliver volatile compounds. The present study has been focused to evaluate the stability potential of matrix-type polymeric patches composed of volatile ethyl anthranilate for prophylaxis against vector-borne diseases. Ethyl anthranilate-loaded matrix-type polymeric patches were fabricated by solvent evaporation method on an impermeable backing membrane and attached to temporary release liners. Stability testing of the polymeric patches was performed as per the International Conference on Harmonization (ICH) guidelines for 6 months under accelerated conditions. In addition, the quantification of residual solvents was also performed as per the ICH guidelines. After conducting the stability studies for 6 months, the optimized patches showed the best possible results with respect to uniformity of drug content, physical appearance, and other analytical parameters. Furthermore, the amount of residual solvent was found well below the accepted limit. Thus, the present report outlined the analytical parameters to be evaluated to ensure the stability of a certain devices consisting of volatile compounds.

Keywords: Controlled release; Ethyl 2-aminobenzoate; ICH guidelines; Insect repellent; Polymeric patch.

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Conflict of interest statement

Conflicts of interest

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Scanning electron microscopy (A) at Day 0 and (B) at Day 180.
Figure 2
Figure 2
Energy dispersive X-ray spectroscopy (A) at Day 0 and (b) at Day 180.
Figure 3
Figure 3
Fourier transform infrared spectroscopy at Day 0 and Day 180.
Figure 4
Figure 4
Differential scanning calorimetry at Day 0 and Day 180.
Figure 5
Figure 5
Thermo gravimetric analysis at Day 0 and Day 180.
Figure 6
Figure 6
X-ray diffraction at Day 0 and Day 180.
Figure 7
Figure 7
Chromatogram of (A) standard solution of chloroform (100 μg/mL) and (B) patch.
See this image and copyright information in PMC

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