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. 1988 Jul 1;241(4861):58-62.
doi: 10.1126/science.2898810.

Purification and characterization of mouse hematopoietic stem cells

G J Spangrude  1 , S Heimfeld, I L Weissman
Affiliations

Purification and characterization of mouse hematopoietic stem cells

G J Spangrude et al. Science. .

Erratum in

  • Science 1989 Jun 2;244(4908):1030

Abstract

Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.

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