Review
doi: 10.1016/s0264-410x(88)80019-7.
Safe, live Vibrio cholerae vaccines?
Affiliations
- PMID: 2898843
- DOI: 10.1016/s0264-410x(88)80019-7
Item in Clipboard
Review
Safe, live Vibrio cholerae vaccines?
Vaccine.
1988 Apr.
Abstract
Mutants of Vibrio cholerae defective in intestinal colonization have been constructed. Characterization of these mutants has led to the identification of a gene cluster involved in the assembly of a pilus colonization factor called TCP. The tcp operon has been cloned and strains of V. cholerae have been constructed that overproduce this pilus and the B subunit of cholera toxin. Together these studies may contribute to the eventual construction of efficient live and killed, oral cholera vaccines.
Similar articles
-
Pathogenic and vaccine significance of toxin-coregulated pili of Vibrio cholerae E1 Tor.J Biotechnol. 1999 Aug 20;73(2-3):109-17. doi: 10.1016/s0168-1656(99)00114-5. J Biotechnol. 1999. PMID: 10486921 Review.
-
A Vibrio cholerae classical TcpA amino acid sequence induces protective antibody that binds an area hypothesized to be important for toxin-coregulated pilus structure.Infect Immun. 2004 Oct;72(10):6050-60. doi: 10.1128/IAI.72.10.6050-6060.2004. Infect Immun. 2004. PMID: 15385509 Free PMC article.
-
Production of putative enhanced oral cholera vaccine strains that express toxin-coregulated pilus.PLoS One. 2017 Apr 6;12(4):e0175170. doi: 10.1371/journal.pone.0175170. eCollection 2017. PLoS One. 2017. PMID: 28384206 Free PMC article.
-
Use of the Vibrio cholerae irgA gene as a locus for insertion and expression of heterologous antigens in cholera vaccine strains.Vaccine. 1993 Oct;11(13):1327-35. doi: 10.1016/0264-410x(93)90103-5. Vaccine. 1993. PMID: 8296486
-
Vibrio cholerae CVD103-HgR live oral attenuated vaccine: construction, safety, immunogenicity, excretion and non-target effects.Dev Biol Stand. 1995;84:237-44. Dev Biol Stand. 1995. PMID: 7796960 Review.
Cited by
-
Differential transcription of the tcpPH operon confers biotype-specific control of the Vibrio cholerae ToxR virulence regulon.Infect Immun. 1999 Oct;67(10):5117-23. doi: 10.1128/IAI.67.10.5117-5123.1999. Infect Immun. 1999. PMID: 10496885 Free PMC article.
-
Type 4 pilus biogenesis and type II-mediated protein secretion by Vibrio cholerae occur independently of the TonB-facilitated proton motive force.J Bacteriol. 2002 Apr;184(8):2305-9. doi: 10.1128/JB.184.8.2305-2309.2002. J Bacteriol. 2002. PMID: 11914364 Free PMC article.
-
Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae.Microbiol Mol Biol Rev. 1998 Dec;62(4):1301-14. doi: 10.1128/MMBR.62.4.1301-1314.1998. Microbiol Mol Biol Rev. 1998. PMID: 9841673 Free PMC article. Review.
-
ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae.Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1641-5. doi: 10.1073/pnas.88.5.1641. Proc Natl Acad Sci U S A. 1991. PMID: 2000374 Free PMC article.
-
Localization of protective epitopes within the pilin subunit of the Vibrio cholerae toxin-coregulated pilus.Infect Immun. 1991 Jan;59(1):114-8. doi: 10.1128/iai.59.1.114-118.1991. Infect Immun. 1991. PMID: 1702758 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
