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Comment
. 2017 Nov;27(11):785-786.
doi: 10.1016/j.tcb.2017.09.003. Epub 2017 Oct 4.

Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma

Matyas Abel Tsegaye  1 , Zachary T Schafer  2
Affiliations
Comment

Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma

Matyas Abel Tsegaye et al. Trends Cell Biol. 2017 Nov.

Abstract

A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated protein kinase (AMPK)-mediated anoikis, and consequently promotes PDAC development and metastasis.

Keywords: Glucose transporter 1; anoikis; glucose metabolism; pancreatic ductal adenocarcinoma.

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  • Fluorescence nanoscopy in cell biology.
    Sahl SJ, Hell SW, Jakobs S. Sahl SJ, et al. Nat Rev Mol Cell Biol. 2017 Nov;18(11):685-701. doi: 10.1038/nrm.2017.71. Epub 2017 Sep 6. Nat Rev Mol Cell Biol. 2017. PMID: 28875992 Review.

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