Comment
doi: 10.1016/j.tcb.2017.09.003.
Epub 2017 Oct 4.
Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma
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- PMID: 28988620
- DOI: 10.1016/j.tcb.2017.09.003
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Comment
Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma
Trends Cell Biol.
2017 Nov.
Abstract
A hallmark of pancreatic ductal adenocarcinoma cancer (PDAC) cells is metabolic reprogramming that facilitates tumor progression. In a recent paper published in Molecular Cell, Nagarajan et al. discover that paraoxonase (PON)2 stimulates glucose transporter (GLUT)1-mediated glucose uptake, prevents AMP-activated protein kinase (AMPK)-mediated anoikis, and consequently promotes PDAC development and metastasis.
Keywords: Glucose transporter 1; anoikis; glucose metabolism; pancreatic ductal adenocarcinoma.
Copyright © 2017 Elsevier Ltd. All rights reserved.
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