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. 2017 Sep-Oct;21(5):776-780.
doi: 10.4103/ijem.IJEM_206_17.

Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes

Anjali Amit Bhatt  1 , Priya K Choudhari  2 , Rutuja R Mahajan  2 , Mehmood G Sayyad  3 , Devi D Pratyush  4 , Imtiaz Hasan  5 , Rajesh S Javherani  1 , Manish M Bothale  1 , Vedavati B Purandare  1 , Ambika Gopalakrishnan Unnikrishnan  1
Affiliations

Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes

Anjali Amit Bhatt et al. Indian J Endocrinol Metab. 2017 Sep-Oct.

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is considered to be an inevitably progressive disease. Complex therapies add to the financial and psychological burden. Very low-calorie diets (LCDs) are emerging as an option in the management of type 2 diabetes.

Methods: We performed a clinical audit of patients with T2DM who received 12 weeks of LCD.

Results: This case series documents that 6 out of 12 participants (median baseline HbA1c 9%) achieved HbA1c level in nondiabetes range with LCD despite stopping all antidiabetes medications. There was an improvement in serum triglycerides, HDL cholesterol, total cholesterol, C-Reactive protein, urine microalbumin, liver transaminases, liver fat and the indices of insulin resistance, beta cell secretory capacity, and insulin sensitivity.

Conclusion: If long-term follow-up proves sustained benefits, such dietary restriction may be an alternative to more drastic options for reversal of type 2 diabetes. This may also help in changing the treatment perspective of a newly detected T2DM from an incurable and inevitably progressive disease to a potentially reversible disease.

Keywords: Nutrition; obesity; reversal; type 2 diabetes; very low-calorie diet.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Changes in HbA1c and glycemic indices in responders and nonresponders
See this image and copyright information in PMC

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