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Comment
. 2018 Jul;15(7):654-656.
doi: 10.1038/cmi.2017.101. Epub 2017 Oct 9.

The ESCRT protein CHMP5 escorts αβ T cells through positive selection

Glendon S Wu  1   2 , Craig H Bassing  3   4
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Comment

The ESCRT protein CHMP5 escorts αβ T cells through positive selection

Glendon S Wu et al. Cell Mol Immunol. 2018 Jul.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
CD4+CD8+ double-positive (DP) thymocytes undergo positive selection by interacting with thymic epithelial cells in the cortex. Low-affinity interactions between TCR and peptide: MHC stabilizes the ESCRT protein CHMP5 by phosphorylation of serine 26 and 30 by an unidentified kinase. This phosphorylation recruits the deubiquitylating enzyme USP8, which removes ubiquitin moieties at lysine 100. In this manner, CHMP5 is protected from proteasomal degradation. As a result, CHMP5 binds to and stabilizes the anti-apoptotic factor Bcl2, presumably shielding it away from degradative reactive oxygen species.
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References

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