. 2017 Nov;49(11):1576-1583.

doi: 10.1038/ng.3973. Epub 2017 Oct 9.

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Zhiqiang Li^{1

2

3

4}, Jianhua Chen^{2

5}, Hao Yu^{6

7

8}, Lin He^{2

4}, Yifeng Xu⁵, Dai Zhang^{6

7

9}, Qizhong Yi¹⁰, Changgui Li¹¹, Xingwang Li², Jiawei Shen², Zhijian Song², Weidong Ji^{4

12}, Meng Wang², Juan Zhou², Boyu Chen², Yahui Liu², Jiqiang Wang², Peng Wang¹³, Ping Yang¹³, Qingzhong Wang², Guoyin Feng⁵, Benxiu Liu¹⁴, Wensheng Sun¹⁴, Baojie Li², Guang He², Weidong Li², Chunling Wan², Qi Xu¹⁵, Wenjin Li², Zujia Wen², Ke Liu², Fang Huang², Jue Ji², Stephan Ripke^{16

17

18}, Weihua Yue^{6

7}, Patrick F Sullivan^{19

20}, Michael C O'Donovan²¹, Yongyong Shi^{1

2

3

4

10

12}

Affiliations

¹ Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China.
² Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, China.
³ Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China.
⁴ Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁵ Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.
⁷ Institute of Mental Health, Sixth Hospital, Peking University, Beijing, China.
⁸ Department of Psychiatry, Jining Medical University, Jining, China.
⁹ Peking-Tsinghua Joint Center for Life Sciences/PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
¹⁰ Department of Psychiatry, First Teaching Hospital of Xinjiang Medical University, Urumqi, China.
¹¹ Shandong Provincial Key Laboratory of Metabolic Disease and Metabolic Disease Institute of Qingdao University, Qingdao, China.
¹² Changning Mental Health Center, Shanghai, China.
¹³ Wuhu Fourth People's Hospital, Wuhu, China.
¹⁴ Longquan Mountain Hospital of Guangxi Province, Liuzhou, China.
¹⁵ National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁶ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁷ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
¹⁸ Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
¹⁹ Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
²⁰ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
²¹ MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.

PMID: 28991256
DOI: 10.1038/ng.3973

Free article

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Zhiqiang Li et al. Nat Genet. 2017 Nov.

Free article

. 2017 Nov;49(11):1576-1583.

doi: 10.1038/ng.3973. Epub 2017 Oct 9.

Authors

Affiliations

¹ Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China.
² Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, China.
³ Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China.
⁴ Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁵ Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.
⁷ Institute of Mental Health, Sixth Hospital, Peking University, Beijing, China.
⁸ Department of Psychiatry, Jining Medical University, Jining, China.
⁹ Peking-Tsinghua Joint Center for Life Sciences/PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
¹⁰ Department of Psychiatry, First Teaching Hospital of Xinjiang Medical University, Urumqi, China.
¹¹ Shandong Provincial Key Laboratory of Metabolic Disease and Metabolic Disease Institute of Qingdao University, Qingdao, China.
¹² Changning Mental Health Center, Shanghai, China.
¹³ Wuhu Fourth People's Hospital, Wuhu, China.
¹⁴ Longquan Mountain Hospital of Guangxi Province, Liuzhou, China.
¹⁵ National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁶ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
¹⁷ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
¹⁸ Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
¹⁹ Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA.
²⁰ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
²¹ MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.

PMID: 28991256
DOI: 10.1038/ng.3973

Abstract

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia.

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Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

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Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

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