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Randomized Controlled Trial
. 2017 Oct 8;7(10):e017540.
doi: 10.1136/bmjopen-2017-017540.

MEDication reminder APPs to improve medication adherence in Coronary Heart Disease (MedApp-CHD) Study: a randomised controlled trial protocol

Karla Santo  1   2 , Clara K Chow  1   2   3 , Aravinda Thiagalingam  2   3   4 , Kris Rogers  5 , John Chalmers  2   6 , Julie Redfern  1   2
Affiliations
Randomized Controlled Trial

MEDication reminder APPs to improve medication adherence in Coronary Heart Disease (MedApp-CHD) Study: a randomised controlled trial protocol

Karla Santo et al. BMJ Open. .

Abstract

Introduction: The growing number of smartphone health applications available in the app stores makes these apps a promising tool to help reduce the global problem of non-adherence to long-term medications. However, to date, there is limited evidence that available medication reminder apps are effective. This study aims to determine the impact of medication reminder apps on adherence to cardiovascular medication when compared with usual care for people with coronary heart disease (CHD) and to determine whether an advanced app compared with a basic app is associated with higher adherence.

Methods and analysis: Randomised controlled trial with follow-up at 3 months to evaluate the feasibility and effectiveness of medication reminder apps on medication adherence compared with usual care. An estimated sample size of 156 patients with CHD will be randomised to one of three groups (usual care group, basic medication reminder app group and advanced medication reminder app group). The usual care group will receive standard care for CHD with no access to a medication reminder app. The basic medication reminder app group will have access to a medication reminder app with a basic feature of providing simple daily reminders with no interactivity. The advanced medication reminder app group will have access to a medication reminder app with additional interactive and customisable features. The primary outcome is medication adherence measured by the eight-item Morisky Medication Adherence Scale at 3 months. Secondary outcomes include clinical measurements of blood pressure and cholesterol levels, and medication knowledge. A process evaluation will also be performed to assess the feasibility of the intervention by evaluating the acceptability, utility and engagement with the apps.

Ethics and dissemination: Ethical approval has been obtained from the Western Sydney Local Health Network Human Research Ethics Committee (AU/RED/HREC/1/WMEAD/3). Study findings will be disseminated via usual scientific forums.

Trial registration number: ACTRN12616000661471; Pre-results.

Keywords: Medication adherence; applications; apps; coronary heart disease; eHealth; mHealth; medication compliance; mobile phone; randomised controlled trial; smartphone.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
MedApp-CHD flow diagram. MedApp-CHD, MEDication reminder APPs to improve medication adherence in Coronary Heart Disease.
See this image and copyright information in PMC

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