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Comment
. 2018 Jul;67(7):1369-1370.
doi: 10.1136/gutjnl-2017-315306. Epub 2017 Oct 9.

Proton pump inhibitor use associated with changes in gut microbiota composition

Kelly R Reveles  1   2 , Caitlin N Ryan  3 , Luisa Chan  3 , Reese A Cosimi  1   4 , Wanda L Haynes  5
Affiliations
Comment

Proton pump inhibitor use associated with changes in gut microbiota composition

Kelly R Reveles et al. Gut. 2018 Jul.
No abstract available

Keywords: intestinal microbiology; proton pump inhibition.

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Conflict of interest statement

Competing interests: None declared.

Comment on

  • Proton pump inhibitors affect the gut microbiome.
    Imhann F, Bonder MJ, Vich Vila A, Fu J, Mujagic Z, Vork L, Tigchelaar EF, Jankipersadsing SA, Cenit MC, Harmsen HJ, Dijkstra G, Franke L, Xavier RJ, Jonkers D, Wijmenga C, Weersma RK, Zhernakova A. Imhann F, et al. Gut. 2016 May;65(5):740-8. doi: 10.1136/gutjnl-2015-310376. Epub 2015 Dec 9. Gut. 2016. PMID: 26657899 Free PMC article.
  • Proton pump inhibitors alter the composition of the gut microbiota.
    Jackson MA, Goodrich JK, Maxan ME, Freedberg DE, Abrams JA, Poole AC, Sutter JL, Welter D, Ley RE, Bell JT, Spector TD, Steves CJ. Jackson MA, et al. Gut. 2016 May;65(5):749-56. doi: 10.1136/gutjnl-2015-310861. Epub 2015 Dec 30. Gut. 2016. PMID: 26719299 Free PMC article.

References

    1. Imhann F, Bonder MJ, Vich Vila A, et al. Proton pump inhibitors affect the gut microbiome. Gut 2016;65:740–8. 10.1136/gutjnl-2015-310376 - DOI - PMC - PubMed
    1. Jackson MA, Goodrich JK, Maxan ME, et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut 2016;65:749–56. 10.1136/gutjnl-2015-310861 - DOI - PMC - PubMed
    1. Reimer C, Bytzer P. Clinical trial: long-term use of proton pump inhibitors in primary care patients - a cross sectional analysis of 901 patients. Aliment Pharmacol Ther 2009;30:725–32. 10.1111/j.1365-2036.2009.04092.x - DOI - PubMed
    1. O’May GA, Reynolds N, Smith AR, et al. Effect of pH and antibiotics on microbial overgrowth in the stomachs and duodena of patients undergoing percutaneous endoscopic gastrostomy feeding. J Clin Microbiol 2005;43:3059–65. 10.1128/JCM.43.7.3059-3065.2005 - DOI - PMC - PubMed
    1. Sanaka M, Yamamoto T, Kuyama Y. Effects of proton pump inhibitors on gastric emptying: a systematic review. Dig Dis Sci 2010;55:2431–40. 10.1007/s10620-009-1076-x - DOI - PubMed

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