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Randomized Controlled Trial
. 2018 Jan;22(1):127-132.
doi: 10.1007/s10461-017-1913-4.

A Randomized Crossover Study Evaluating the Use and Acceptability of the SILCS Diaphragm Compared to Vaginal Applicators for Vaginal Gel Delivery

Mags Beksinska  1 , Ross Greener  2 , Jenni Smit  2 , Busi Maphumulo  2 , Nonhlanhla Mphili  2 , Maggie Kilbourne-Brook  3 , Patricia S Coffey  3
Affiliations
Randomized Controlled Trial

A Randomized Crossover Study Evaluating the Use and Acceptability of the SILCS Diaphragm Compared to Vaginal Applicators for Vaginal Gel Delivery

Mags Beksinska et al. AIDS Behav. 2018 Jan.

Abstract

Introduction: This study aimed to assess acceptability and preferences for the SILCS diaphragm for vaginal gel delivery compared to a prefilled applicator.

Methods: A randomized crossover study among 115 women in South Africa, using both methods during five sex acts.

Results: We found no significant differences in acceptability between the two products. Experience of gel leakage after sex was greater when inserted via applicator. More women were interested in SILCS/gel for multipurpose protection (68%) than in either SILCS alone (17%) or microbicide gel alone (14%).

Conclusions: A SILCS gel delivery system for multipurpose prevention seems feasible and acceptable.

Keywords: Barrier methods; Diaphragm; Gel; MPT; Multipurpose technology; Vaginal applicator.

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